Ronald B. Villanueva, Giuseppe Barbesino, David A. Greenberg, Erlinda Concepcion, Stefania Tucci, Terry F. Davies, Yaron Tomer
{"title":"The BTK Gene as Candidate Gene for Graves’ Disease","authors":"Ronald B. Villanueva, Giuseppe Barbesino, David A. Greenberg, Erlinda Concepcion, Stefania Tucci, Terry F. Davies, Yaron Tomer","doi":"10.1002/1438-826X(200009)1:2<99::AID-GNFD99>3.0.CO;2-R","DOIUrl":null,"url":null,"abstract":"<p>Graves’ disease (GD) results from an interplay of genetic factors and environmental triggers. We examined the immunoregulatory gene, Bruton’s tyrosine kinase (BTK), a candidate gene located in a region on chromosome Xq21.33−22 which we have previously found to be linked to GD and designated as GD-3. The study aimed to identify whether BTK was GD-3. No association was found between GD and alleles of the marker DXS178 and the A/C SNP. We concluded that BTK is not the GD-3 Graves’ disease susceptibility gene on chromosome Xq21.33−22.</p>","PeriodicalId":100573,"journal":{"name":"Gene Function & Disease","volume":"1 2","pages":"99-101"},"PeriodicalIF":0.0000,"publicationDate":"2001-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/1438-826X(200009)1:2<99::AID-GNFD99>3.0.CO;2-R","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gene Function & Disease","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/1438-826X%28200009%291%3A2%3C99%3A%3AAID-GNFD99%3E3.0.CO%3B2-R","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Graves’ disease (GD) results from an interplay of genetic factors and environmental triggers. We examined the immunoregulatory gene, Bruton’s tyrosine kinase (BTK), a candidate gene located in a region on chromosome Xq21.33−22 which we have previously found to be linked to GD and designated as GD-3. The study aimed to identify whether BTK was GD-3. No association was found between GD and alleles of the marker DXS178 and the A/C SNP. We concluded that BTK is not the GD-3 Graves’ disease susceptibility gene on chromosome Xq21.33−22.
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