Green synthesis of silver nanoparticles from Morinda tinctoria Roxb and scrutiny of its multi facet on biomedical applications

Abstract

Objective : This research work focus on synthesis of silver nanoparticles from Morinda tinctoria Roxb leaves. The synthesis of nanoparticles from biological processes is evolving a new era of research interests in nanotechnology. Silver nanoparticles are usually synthesized by chemicals. M. tinctoria Roxb leaves are reputed plant in traditional system of medicine and it is used for the treatment of illness such as arthritis, cancer, gastric ulcer and other heart disease etc. Methods : The present study the leaves were collected, air dried and extract silver nanoparticles. The extract was subjected to characterization, antimicrobial activity, antidiabetic and anticancer activity using M. tinctoria Roxb leaves following standard procedures. Results : Silver nanoparticles study showed the evaluation of antioxidant and anticancer activity of M. tinctoria Roxb. Antioxidant activities were done using DPPH antioxidant assay and hydrogen peroxide assay. The anticancer study was conducted to evaluate the in-vitro anticancer activity of green synthesized nanoparticles using human hepatic carcinoma cell lines (HepG2). Conclusions : The leaf extract of silver nanoparticle evaluation showed higher antioxidant activity and anticancer activity in M. tinctoria Roxb.