Vaccine development for Staphylococcal Infectious Disease

Abstract

Staphylococcus aureus is common bacterial pathogen which causes illnesses ranging from minor infections to life threatening diseases. This bacterium has become major cause of hospital acquired infections. It affects patients who has already weak immune system .It is mostly spread to others by contaminated hands and Skin. Due to skin damages, S.aureus may gain access to tissues or the blood stream and cause infection. These bacteria can survive on dry surfaces and increasing the chance of transmission. It cannot be eradicated by antibiotics like Methicillin, Vanomycin, etc, because it is an antibiotic resistant pathogen. So there is another way to prevent this pathogen’s infection by vaccination. In our lab, few experimental trials were conducted regarding identification and recommendation of various immunogens for vaccine development. The important Immunogens are inactivated cells, peptides, Nucleotides and their fragments .The natural plasmid DNA and their enzyme digested nucleotide fragments produce good immune responses.