Analysis of ultrasound supported antımıcrobıal and antıbıofılm actıvıtıes of dısınfectıon by-product bromochloroacetonıtrıle

Letters in Drug Design & Discovery Pub Date : 2023-05-05 DOI:10.2174/1570180820666230505085031

Sevda Er

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Abstract

Some microorganism threaten human health by forming biofilm in water systems. Because microorganism in the biofilm structure are more resistant to antimicrobials. Water systems are disinfected with physical methods, such as ultrasonication techniques and chemical disinfectants. Bromochloroacetonitrile is produced as a by-product from algae and fulvic acid sources during water chlorination. This study aimed to investigate the antimicrobial and antibiofilm effects of bromochloroacetonitrile on some bacteria alone and with ultrasound treatment. The study used Escherichia coli ATCC 25922, Klebsiella pneumoniae MCTC 13438, and Staphylococcus aureus ATCC 25923 strains. The antimicrobial and antibiofilm activities of the test substance were analyzed alone with bromochloroacetonitrile and Ultrasound-assisted. Minimum Inhibitory Concentration values of the test substance against Escherichia coli ATCC 25922, Klebsiella pneumoniae MCTC 13438, and Staphylococcus aureus ATCC 25923 strains were 25, 25 and 50 mM, respectively, and Minimum Bactericidal Concentration values were 50, >50, and >50 mM, respectively. The obtained data show that bromochloroacetonitrile is a potential disinfection agent that can be used against biofilm formation in water systems. Besides, it was revealed that when ultrasound treatment was applied with bromochloroacetonitrile, it showed 100% antibiofilm activity on E. coli and K. pneumoniae and 79.45% antibiofilm activity on S. aureus strains. The obtained data show that bromochloroacetonitrile is a potential disinfection agent that can be used against biofilm formation in water systems. This study is preliminary and planned to reveal the cytotoxic effects of bromochloroacetonitrile on healthy human skin and liver cells in the following study. These results will contribute to the literature, as no study reveals the antimicrobial and antibiofilm activities of bromochloroacetonitrile.

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超声载体antımıcrobıal及dısınfectıon副产物bromochloroacetonıtrıle的分析

一些微生物在水体中形成生物膜，威胁着人类的健康。因为生物膜结构中的微生物对抗菌剂的抗性更强。水系统用物理方法消毒，如超声波技术和化学消毒剂。溴氯乙腈是藻类和黄腐酸在水氯化过程中产生的副产物。本研究旨在探讨溴氯乙腈对某些细菌的抗菌和抗生物膜作用。该研究使用了大肠杆菌ATCC 25922、肺炎克雷伯菌MCTC 13438和金黄色葡萄球菌ATCC 25923菌株。用溴氯乙腈和超声辅助法单独测定该物质的抗菌活性和抗菌膜活性。试验物质对大肠杆菌ATCC 25922、肺炎克雷伯菌MCTC 13438、金黄色葡萄球菌ATCC 25923菌株的最低抑菌浓度分别为25、25、50 mM，最低杀菌浓度分别为50、50、50 mM。所得数据表明，溴氯乙腈是一种潜在的消毒剂，可用于水系统中生物膜的形成。此外，经超声处理的溴氯乙腈对大肠杆菌和肺炎克雷伯菌的抗菌活性为100%，对金黄色葡萄球菌的抗菌活性为79.45%。所得数据表明，溴氯乙腈是一种潜在的消毒剂，可用于水系统中生物膜的形成。本研究是初步的，计划在后续研究中揭示溴氯乙腈对健康人皮肤和肝细胞的细胞毒性作用。这些结果将有助于文献，因为没有研究揭示溴氯乙腈的抗菌和抗生物膜活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Letters in Drug Design & Discovery

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