THE CONCEPT OF NITRO-OXIDATIVE STRESS IN ACUTE GENERALIZED PERITONITIS ON THE BACKGROUND OF OBESITY IN EXPERIMENT

Abstract

Obesity was simulated using a high-calorie diet. On the 1st day, the level of NOx metabolites in the blood serum of the group of animals with AGP on the background of obesity was 9 % significantly higher than that of the group of animals with isolated GPP, on the 3rd day – by 8 %, and on the 7th day – by 7 %, respectively (р<0,05). Comparing the indicators of NO-synthase activity in the liver of the rats of the main group and the comparison group, we obtained higher indicators in the animals of the AGP group and the background of obesity during all periods of the experiment: on the 1st day – by 16 %, on the 3rd day – by 14 %, and on the 7th day – by 13 % (р<0,05). The mechanisms of nitrooxidative stress are significantly increased in animals with AGP against the background of obesity during all periods of the experiment, which is confirmed by statistically significantly higher levels of NO-synthase in the liver and the content of nitrates and nitrites in blood serum compared to animals with isolated obe - sity or animals with AGP.