Solubilization of Hydroxypropyl-β-Cyclodextrin on Cholesterol in Aqueous Solution

Abstract

Hydroxypropyl-I²-Cyclodextrin (HP-I²-CD), prepared via reaction of I²-Cyclodextrin (I²-CD) and propylene oxide (PO), is utilized to research solubilization of HP-I²-CD on cholesterol in aqueous solution. HP-I²-CD is characterized by Fourier Transform Infrared Spectrometry (FT-IR), and concentrations of cholesterol solution are measured by ultraviolet and visible (UV VIS) spectrophotometer. The research on optimal synthesis conditions of HP-I²-CD indicates that sodium hydroxide amounts have the most effect on yields of product. The maximum solubilization multiples of HP-I²-CD reaches 15, below which molecular rate of HP-I²-CD and cholesterol in inclusion complex is 1:1.