Effects of aspirin combined with atorvastatin on hypertensive patients with diabetes mellitus

Abstract

Objective To investigate the effects of aspirin combined with atorvastatin on hypertensive patients with diabetes mellitus. Methods One hundred hypertensive patients with diabetes mellitus admitted to the First Hospital of Shanxi Medical University from January 2016 to December 2017 were selected and divided into aspirin group and aspirin combined with atorvastatin group (combined treatment group) according to random number table method, with 50 cases in each group. Patients in aspirin group were treated with aspirin, 100 mg/d; while patients in combined treatment group were treated with aspirin, 100 mg/d, and atorvastatin, 20 mg/d. Blood lipid, urinary albumin, β2-microglobulin (β2-MG), urinary albumin excretion rate (UAER), cardioankle vascular index (CAVI) and ankle brachial index (ABI) of the two groups were measured and compared before and 20 weeks after treatment, and the incidences of non fatal myocardial infarction of the two groups were compared and analyzed by follow-up. Results Compared with preoperative levels, the levels of total cholesterol and low-density lipoprotein cholesterol of the two groups were reduced, and the levels of CAVI and ABI were improved after treatment (P 0.05). However, the urinary albumin, triacylglycerol, UAER and β2-MG in the combined treatment group were decreased after treatment (P<0.05). During the median follow-up period, the incidence of major endpoints in non fatal myocardial infarction in aspirin group was higher than that in combined treatment group (P<0.05). Multiple stepwise regression analysis showed that the risk factors of arterial stiffness and microalbuminuria were diastolic pressure, systolic pressure, 2 h postprandial blood glucose and fasting blood glucose. Conclusions The combined use of aspirin and atorvastatin can significantly reduce the level of urinary microprotein in patients with hypertension and diabetes mellitus, alleviate arterial stiffness, effectively reduce the incidence of non fatal myocardial infarction. And the study finds that arterial stiffness and microalbuminuria are directly related to blood pressure and blood glucose level. Key words: Aspirin; Atorvastatin; Hypertension; Diabetes mellitus; Arterial stiffness; Non fatal myocardial infarction