Localization of C-Fos-Induced Growth Factor (Figf) mRNA Expression in the Mouse Uterus during Implantation

Charles A. Scott, Kirsten Eckstrum, B. Bany
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引用次数: 5

Abstract

The purpose of this study was to characterize the localization of Figf mRNA in the mouse uterus during embryo implantation. Strong Figf mRNA hybridization signals were seen in the primary decidual zone just after the onset of implantation from Days 4.5–6.5. On Day 7.5, this expression continued around the concept us, but in addition we observed high expression of Figf mRNA in the endothelial cells that line the forming vascular sinusoids in the lateral me some trial decidua. Interestingly, on Days 8.5 this high expression continued in the endothelial cells of sinusoids in the lateral me some trial decidual tissue but not in the decidual cells surrounding the concept us. As implantation and placental development finished, Figf mRNA expression remained in the endothelial cells of the sinusoids and spiral arterioles of the decidua basalis. Interestingly, Flt4 mRNA was localized to the endothelial cells lining the sinusoids that form during implantation. Since the endothelial cells of the me some trial sinusoids exhibit a high level of proliferation, we speculate that FIGF-FLT4 signaling may play a role in their formation and function during implantation. This work will provide a basis for further research on the potential role of FIGF-FLT4 signaling in endometrial angiogenesis during implantation in mice.
c - fos诱导生长因子(Figf) mRNA在小鼠子宫着床过程中的表达定位
本研究的目的是表征胚胎着床过程中Figf mRNA在小鼠子宫中的定位。在着床后的第4.5-6.5天,在初级蜕膜区可见到强烈的Figf mRNA杂交信号。在第7.5天,这种表达继续围绕着我们的概念,但除此之外,我们还观察到在一些蜕膜外侧形成血管窦的内皮细胞中Figf mRNA的高表达。有趣的是,在第8.5天,这种高表达继续在侧壁的一些试验蜕膜组织的窦内皮细胞中存在,但在概念膜周围的蜕膜细胞中没有。随着胚胎着床和胎盘发育完成,基底蜕膜窦状动脉和螺旋小动脉内皮细胞中仍有Figf mRNA的表达。有趣的是,Flt4 mRNA定位于植入过程中形成的窦状体内皮细胞。由于一些试验窦的内皮细胞表现出高水平的增殖,我们推测FIGF-FLT4信号可能在其植入过程中的形成和功能中发挥作用。本工作将为进一步研究FIGF-FLT4信号在小鼠着床过程中子宫内膜血管生成中的潜在作用提供基础。
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