Raluca-Ioana Stefan , Jacobus F van Staden , Hassan Y Aboul-Enein
{"title":"Molecular recognition in chiral discrimination","authors":"Raluca-Ioana Stefan , Jacobus F van Staden , Hassan Y Aboul-Enein","doi":"10.1016/S1463-0184(00)00047-2","DOIUrl":null,"url":null,"abstract":"<div><p><span>The importance of obtaining reliable detection systems for enantiomers' assays increases with the necessity of chiral discrimination between the enantiomers of raw materials from the </span>pharmaceutical industry<span>. The utilization of electrochemical sensors in molecular recognition<span> of chiral substances becomes a very accurate and precise alternative for the structural analysis as well as for the chromatographic techniques. The reliability of the response characteristics as well as of the analytical information obtained by using electrochemical sensors is strictly correlated with the design of the sensors. The most reliable design is that of carbon paste based sensors; this design was adopted for the construction of potentiometric, enantioselective membrane electrodes as well as for the construction of the amperometric biosensors, and immunosensors. However, it is also necessary to look for more reliable chiral selectors.</span></span></p></div>","PeriodicalId":10766,"journal":{"name":"Crystal Engineering","volume":"4 2","pages":"Pages 113-118"},"PeriodicalIF":0.0000,"publicationDate":"2001-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1463-0184(00)00047-2","citationCount":"17","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Crystal Engineering","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1463018400000472","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 17
Abstract
The importance of obtaining reliable detection systems for enantiomers' assays increases with the necessity of chiral discrimination between the enantiomers of raw materials from the pharmaceutical industry. The utilization of electrochemical sensors in molecular recognition of chiral substances becomes a very accurate and precise alternative for the structural analysis as well as for the chromatographic techniques. The reliability of the response characteristics as well as of the analytical information obtained by using electrochemical sensors is strictly correlated with the design of the sensors. The most reliable design is that of carbon paste based sensors; this design was adopted for the construction of potentiometric, enantioselective membrane electrodes as well as for the construction of the amperometric biosensors, and immunosensors. However, it is also necessary to look for more reliable chiral selectors.
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