Skin and Gut Microbiota in Psoriasis: A Systematic Review

Q1 Medicine

Human Microbiome Journal Pub Date : 2020-06-02 DOI:10.5772/intechopen.92686

Atiya Rungjang, J. Meephansan, H. Thio

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引用次数: 3

Abstract

Paying attention to a microbial approach may lead to improvements in diagnosis, treatment, prevention, and prognosis of psoriasis. A systematic review was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines searching strategy to identify the pattern of the microbiome and the association of skin and gut microbiota with psoriasis, including the factors that may affect the results of the microbial study. In total, 16 studies were included in this systematic review. Ten studies investigated the skin microbiome, of which six studies were cross-sectional and four studies were prospective studies. Six studies investigated the gut microbiome, including five cross-sectional studies and one prospective study. The understanding of the relationship between microbiota and psoriasis may lead to diagnostics and treatment improvements. Currently, there is a slight consensus on some specific features that define psoriasis. However, no specific taxa have been identified as biomarkers of the disease, even from large-scale cohort studies. Thus, future cohort studies with standardized methodologies and proof-of-concept investigations in animal models may uncover the role of microbiota and the microbial pathways in psoriasis.

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银屑病的皮肤和肠道微生物群:系统综述

重视微生物方法可能会改善牛皮癣的诊断、治疗、预防和预后。根据PRISMA(系统评价和荟萃分析首选报告项目)指南搜索策略进行系统评价，以确定微生物群的模式以及皮肤和肠道微生物群与牛皮癣的关联，包括可能影响微生物研究结果的因素。本系统综述共纳入16项研究。10项研究调查了皮肤微生物组，其中6项研究是横断面研究，4项研究是前瞻性研究。六项研究调查了肠道微生物组，包括五项横断面研究和一项前瞻性研究。了解微生物群与牛皮癣之间的关系可能会导致诊断和治疗的改进。目前，对牛皮癣的一些具体特征有轻微的共识。然而，即使在大规模队列研究中，也没有特定的分类群被确定为该疾病的生物标志物。因此，未来采用标准化方法的队列研究和动物模型的概念验证调查可能会揭示微生物群和微生物途径在牛皮癣中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Microbiome Journal Medicine-Infectious Diseases

自引率

0.00%

发文量

期刊介绍： The innumerable microbes living in and on our bodies are known to affect human wellbeing, but our knowledge of their role is still at the very early stages of understanding. Human Microbiome is a new open access journal dedicated to research on the impact of the microbiome on human health and disease. The journal will publish original research, reviews, comments, human microbe descriptions and genome, and letters. Topics covered will include: the repertoire of human-associated microbes, therapeutic intervention, pathophysiology, experimental models, physiological, geographical, and pathological changes, and technical reports; genomic, metabolomic, transcriptomic, and culturomic approaches are welcome.