Fertility Preservation in Women With Malignancy: Future Endeavors

Clinical Medicine Insights-Reproductive Health Pub Date : 2019-01-01 DOI:10.1177/1179558119872490

Z. Blumenfeld

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引用次数: 8

Abstract

The area of fertility preservation is constantly developing. To date, the only noninvestigational and unequivocally accepted methods for fertility preservation are cryopreservation of embryos and unfertilized oocytes. This article is one of several in a monogram on fertility preservation. The debate, pros and cons, and equivocal data on the use of GnRH analogues for fertility preservation are elaborated by 3 other manuscripts, in this monogram. A repeat of the arguments, pros and cons of this debatable issue, would be a repetition and redundancy of what is already included in this monogram. The subject of ovarian cryopreservation for fertility preservation is also elaborated by several other authors in this monogram. It is possible that, in the not too far future, the technologies of in vitro maturation of primordial follicles to metaphase 2 oocytes, and the “artificial ovary,” will turn clinically available. These technologies may bypass the risk of resuming malignancy by autotransplantation of cryopreserved-thawed ovarian tissue in leukemia and diseases where malignant cells may persist in the cryopreserved ovarian tissue. We summarize here the suggested options for future endeavors in fertility preservation.

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保留生育能力的妇女恶性肿瘤:未来的努力

生育保存领域在不断发展。迄今为止，唯一的非研究性和明确接受的生育保存方法是胚胎和未受精卵母细胞的冷冻保存。这篇文章是关于生育能力保存的几篇文章之一。关于使用GnRH类似物保存生育能力的争论，赞成和反对，以及模棱两可的数据，在这个字母组合中由其他3份手稿详细阐述。重复这个有争议的问题的论点，赞成和反对，将是重复和冗余已经包含在这个字母组合中。卵巢冷冻保存保存生育能力的主题也阐述了其他几位作者在这个字母组合。在不久的将来，从原始卵泡到中期卵母细胞的体外成熟技术和“人工卵巢”可能会进入临床应用。这些技术可以避免在白血病和恶性细胞可能持续存在于冷冻卵巢组织的疾病中通过自体移植冷冻解冻卵巢组织恢复恶性肿瘤的风险。我们在此总结建议的选项，为今后的努力生育保存。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Medicine Insights-Reproductive Health OBSTETRICS & GYNECOLOGY-

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： Clinical Medicine Insights: Reproductive Health is a peer reviewed; open access journal, which covers all aspects of Reproduction: Gynecology, Obstetrics, and Infertility, spanning both male and female issues, from the physical to the psychological and the social, including: sex, contraception, pregnancy, childbirth, and related topics such as social and emotional impacts. It welcomes original research and review articles from across the health sciences. Clinical subjects include fertility and sterility, infertility and assisted reproduction, IVF, fertility preservation despite gonadotoxic chemo- and/or radiotherapy, pregnancy problems, PPD, infections and disease, surgery, diagnosis, menopause, HRT, pelvic floor problems, reproductive cancers and environmental impacts on reproduction, although this list is by no means exhaustive Subjects covered include, but are not limited to: • fertility and sterility, • infertility and ART, • ART/IVF, • fertility preservation despite gonadotoxic chemo- and/or radiotherapy, • pregnancy problems, • Postpartum depression • Infections and disease, • Gyn/Ob surgery, • diagnosis, • Contraception • Premenstrual tension • Gynecologic Oncology • reproductive cancers • environmental impacts on reproduction, • Obstetrics/Gynaecology • Women''s Health • menopause, • HRT, • pelvic floor problems, • Paediatric and adolescent gynaecology • PID