Role of GeneXpert in extrapulmonary tuberculosis

IF 0.2 Q4 RESPIRATORY SYSTEM

Egyptian Journal of Chest Diseases and Tuberculosis Pub Date : 2023-07-01 DOI:10.4103/ecdt.ecdt_114_22

Ahmed Azzouz, Raafat T. El-Sokkary, Lamiaa Wafi, Mohammad Khalaf

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引用次数: 0

Abstract

Background Tuberculosis (TB) commonly affects the lung (pulmonary TB). Extrapulmonary TB (EPTB) can involve many systems. Diagnosis is often difficult. EPTB may be misdiagnosed with many other inflammatory, granulomatous, and neoplastic disorders. GeneXpert mycobacterium tuberculosis /rifampicin is a valuable test in diagnosis of pulmonary TB. There is limited research about its diagnostic role in EPTB. Patients and methods The aim of this study was to assess the diagnostic value of GeneXpert in EPTB. Samples from EPTB cases were sent for standard mycobacterial culture and GeneXpert assay. The sensitivity and specificity of GeneXpert were calculated. Results A total of 100 patients were included. Overall, 61 cases were definitely diagnosed as EPTB, whereas 39 cases were negative according to culture. GeneXpert was positive in 40 cases, which represent 65.6% of EPTB cases, and negative in 21 (34.4%) cases. Sensitivity and specificity of GeneXpert was 65.6 and 97.4%, respectively. The positive predictive value and negative predictive value were 97.4 and 64.4%, respectively. Conclusion GeneXpert is a rapid, valuable tool in diagnosis of patients with EPTB. It is a highly specific test with fair sensitivity. A multicenter study with larger sample size is needed to evaluate the diagnostic role of GeneXpert in different sites of EPTB.

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GeneXpert在肺外结核中的作用

结核病(TB)通常影响肺部(肺结核)。肺外结核(EPTB)可累及多个系统。诊断通常很困难。EPTB可能被误诊为许多其他炎症性、肉芽肿性和肿瘤疾病。GeneXpert结核分枝杆菌/利福平是诊断肺结核的一种有价值的检测方法。关于其在EPTB中的诊断作用的研究有限。患者和方法本研究的目的是评估GeneXpert在EPTB中的诊断价值。EPTB病例的样本送去进行标准分枝杆菌培养和GeneXpert检测。计算GeneXpert的敏感性和特异性。结果共纳入100例患者。确诊为EPTB 61例，培养阴性39例。GeneXpert阳性40例，占EPTB病例的65.6%，阴性21例(34.4%)。GeneXpert的敏感性为65.6，特异性为97.4%。阳性预测值为97.4，阴性预测值为64.4%。结论GeneXpert是一种快速、有价值的EPTB诊断工具。这是一种高度特异性的测试，具有相当的灵敏度。需要多中心、更大样本量的研究来评估GeneXpert在EPTB不同部位的诊断作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Egyptian Journal of Chest Diseases and Tuberculosis RESPIRATORY SYSTEM-

自引率

0.00%

发文量

审稿时长

22 weeks

期刊介绍： The journal will cover technical and clinical studies related to health, ethical and social issues in field of The Egyptian Journal of Chest Diseases and Tuberculosis aims to publish and inform readers and all chest physicians of the progress in medical research concerning all aspect of chest diseases. Publications include original articles review articles, editorials, case studies and reports which are relevant to chest diseases. The Journal also aims to highlight recent updates in chest medicine. . Articles with clinical interest and implications will be given preference.