A prospective study of association of deranged liver function tests and renal function tests with severity of preeclampsia

Abstract

Hypertensive disorders represent the most common complication of pregnancy affecting 7 to 15% of all gestations. Amongst these, preeclampsia accounts for 5-7 percent of all pregnancies. Even after considerable research, the cause for preeclampsia remains unclear and there are no useful screening tests in early diagnosis of preeclampsia. The aim of the study was to see the association of deranged liver function tests and renal function tests with severity of preeclampsia.This is a hospital based prospective study and was conducted in the Department of Obstetrics and Gynaecology, SMS medical college, Jaipur from April 2016 to November to find association of deranged liver function tests and renal function tests with severity of preeclampsia. After the informed consent, total 250 women of more than 20 weeks and more than +1 dipstick urine protein were included in this study. Preeclampsia is seen more frequently in nulliparous women than in multiparous women. This study show SGOT and SGPT had a mean value of   60.76u/l ± 22.63 and 62.47 u/l ± 22.36 respectively. Similarly serum creatinine and serum uric acid mean values were 0.58mg/dl± 0.20 and 4.82 mg/dl ± 1.08 respectively. This indicates that women with mild preeclampsia had a relatively stable liver and renal function.  In this SGOT and SGPT had a mean value of   120.76u/l ± 22.63 and 128.47 u/l ± 22.36 respectively. Similarly serum creatinine and serum uric acid mean values were 2.4mg/dl± 0.20 and 10.56 mg/dl ± 1.08 respectively. This indicates that women with severe preeclampsia had a unstable liver and renal function.  Liver and renal involvement is common in preeclampsia and eclampsia. These can be taken as predictors of the disease, asses its severity and manage the patients timely. This can help to reduce the maternal and foetal morbidity to a great extent.