Spectral Structure and Nonlinear Dynamics Properties of Long-Term Interstitial Fluid Glucose

Abstract

The spread of continuous indwelling sensors in the subcutaneous tissue has enabled continuous monitoring of interstitial fluid glucose concentration (ISFG) under daily activities. This technology is considered to enable the development of a method for evaluating glycemic control function by analyzing not only the detailed state of diabetes and other pathological conditions but also the characteristics of glycemic dynamics. To clarify the basic fluctuation characteristics of long-term ISFG, the spectral structure and nonlinear dynamics properties of ISFG obtained by continuous monitoring for 11 days were analyzed in healthy and diabetic subjects.