Exploring “quality” in cord blood transfusion: uncertainties, bionetworks, and collaborations

IF 1.3 4区 医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
B. Lonergan, R. Williams, T. Matsushige, L. Machin
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引用次数: 0

Abstract

Umbilical cord blood unit (CBU) “quantity” continues to grow internationally, while cord blood transplantation (CBT) “quality” remains poorly defined and subject to uncertainty. CBT “quality” is affected by both the product (i.e. CBUs) and CBT processes, with “best practice” varying across countries. To improve overall CBT “quality”, we need to better understand the uncertainty associated with CBUs and CBT processes and how staff manage it. In this qualitative study, we conducted in-depth semi-structured interviews with individuals working in CBT in UK and Japan. We found that understanding of CBT quality by the cord blood community is underpinned by the quality of the CBU, the expertise and collaboration of scientific and clinical stakeholders, trust in collection and testing processes and international accreditation. Importantly, we found that local and individual experience is used to manage uncertainty within CBT, and we propose that selection guidelines should acknowledge the extent of uncertainty in decision-making.
探索脐带血输血的“质量”:不确定性、生物网络和合作
国际上脐带血单位(CBU)“数量”持续增长,而脐带血移植(CBT)“质量”仍然定义不清,且存在不确定性。CBT“质量”受到产品(即cbu)和CBT过程的影响,“最佳做法”因国家而异。为了提高CBT的整体“质量”,我们需要更好地了解与cbu和CBT过程相关的不确定性,以及员工如何管理它。在这项定性研究中,我们对英国和日本从事CBT工作的个人进行了深入的半结构化访谈。我们发现,脐带血社区对CBT质量的理解是由CBU的质量、科学和临床利益相关者的专业知识和合作、对收集和测试过程的信任以及国际认证所支撑的。重要的是,我们发现当地和个人经验被用于管理CBT中的不确定性,我们建议选择指南应该承认决策中的不确定性程度。
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来源期刊
New Genetics and Society
New Genetics and Society 生物-生物工程与应用微生物
CiteScore
4.30
自引率
16.70%
发文量
19
审稿时长
>12 weeks
期刊介绍: New Genetics and Society: Critical Studies of Contemporary Biosciences is a world-leading journal which: -Provides a focus for interdisciplinary and multi-disciplinary, leading-edge social science research on the new genetics and related biosciences; -Publishes theoretical and empirical contributions reflecting its multi-faceted development; -Provides an international platform for critical reflection and debate; -Is an invaluable research resource for the many related professions, including health, medicine and the law, wishing to keep abreast of fast changing developments in contemporary biosciences. New Genetics and Society publishes papers on the social aspects of the new genetics (widely defined), including gene editing, genomics, proteomics, epigenetics and systems biology; and the rapidly developing biosciences such as biomedical and reproductive therapies and technologies, xenotransplantation, stem cell research and neuroscience. Our focus is on developing a better understanding of the social, legal, ethical and policy aspects, including their local and global management and organisation.
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