Cell type–specific actions of Bcl11b in early T-lineage and group 2 innate lymphoid cells

Abstract

Bcl11b binds to distinctive genomic regions with different partners and regulates completely different target genes in pro-T and ILC2 cells. Despite these divergences in Bcl11b function, a shared enhancer supports initial Bcl11b locus opening in both pro-T and ILC2 lineages.