Cell type–specific actions of Bcl11b in early T-lineage and group 2 innate lymphoid cells

H. Hosokawa, Maile Romero-Wolf, Qi Yang, Y. Motomura, D. Levanon, Y. Groner, K. Moro, Tomoaki Tanaka, E. Rothenberg
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引用次数: 40

Abstract

Bcl11b binds to distinctive genomic regions with different partners and regulates completely different target genes in pro-T and ILC2 cells. Despite these divergences in Bcl11b function, a shared enhancer supports initial Bcl11b locus opening in both pro-T and ILC2 lineages.
Bcl11b在早期t系和2组先天淋巴样细胞中的细胞类型特异性作用
在前t细胞和ILC2细胞中,Bcl11b通过不同的伙伴结合到不同的基因组区域,调控完全不同的靶基因。尽管在Bcl11b功能上存在这些差异,但一个共享的增强子在亲t和ILC2谱系中都支持初始的Bcl11b位点开放。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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