Recent progress in apoptosis triggering facilitated by HeLa Studies

Q4 Pharmacology, Toxicology and Pharmaceutics
Maria Constantin, M. Beleaua
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引用次数: 0

Abstract

Abstract Objective: Cancer is a leading cause of death globally, prompting numerous efforts to find effective treatments. HeLa cells, derived from Henrietta Lacks’ cancerous squamous cells, have played a crucial role in cancer research due to their origin, resistance, and rapid growth. They are particularly useful for studying ways of cellular death triggering, or apoptosis, without an immune response. Thus, the objective of this paper was to review the latest publications on the subject of HeLa apoptosis so that a brief view to be available on the otherwise so extended subject. Methodology: To provide a concise review of the extensive research on this topic, a search was conducted using the phrase “HeLa cells apoptosis triggering” on PubMed. The articles that were published in English, in the last 6 years, presenting results sustained by valid morphological and chemical apoptotic changes present in cells, were selected and reviewed. A comprehensive table presenting the apoptotic mechanism exerted by each substance was made to assure a concise presentation of the results. Results: The reviewed studies have shown that many natural substances exhibit pro-apoptotic activity on malignant cells and can be used as chemotherapeutic agents. Some synthetic molecules were showed to have good results too. Important facts about these substances, their intervention site and metabolic modifications are presented in a concise form. The use of nano-carriers for targeted delivery was shown to increase their specificity towards cancerous cells. Conclusions: HeLa cells were a groundbreaking discovery that revolutionized scientific research. Although there is ongoing research towards cancer cures using HeLa cells, there are still many trials and considerations that need to be addressed. With the countless existing HeLa cell lines, the scientific possibilities for research are endless.
HeLa研究促进细胞凋亡触发的最新进展
摘要目的:癌症是全球死亡的主要原因,促使人们努力寻找有效的治疗方法。HeLa细胞来源于Henrietta Lacks的癌状鳞状细胞,由于其起源,抗性和快速生长,在癌症研究中发挥了至关重要的作用。它们对于研究在没有免疫反应的情况下触发细胞死亡或凋亡的方法特别有用。因此,本文的目的是回顾HeLa细胞凋亡这一主题的最新出版物,以便对这一广泛的主题有一个简要的了解。方法:为了对该主题的广泛研究进行简要回顾,我们在PubMed上使用“HeLa细胞凋亡触发”这一短语进行了搜索。我们选择并回顾了近6年来发表的英文文章,这些文章呈现了细胞中存在的有效的形态学和化学凋亡变化的结果。我们制作了一个综合表,展示了每种物质的凋亡机制,以确保结果的简洁呈现。结果:研究表明,许多天然物质对恶性肿瘤细胞具有促凋亡活性,可作为化疗药物。一些合成分子也显示出良好的效果。关于这些物质的重要事实,它们的干预位点和代谢修饰以简明的形式呈现。使用纳米载体进行靶向递送被证明可以增加它们对癌细胞的特异性。结论:海拉细胞是一项突破性的发现,彻底改变了科学研究。尽管目前正在进行利用HeLa细胞治疗癌症的研究,但仍有许多试验和考虑需要解决。有了无数现有的海拉细胞系,科学研究的可能性是无穷无尽的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Marisiensis - Seria Medica
Acta Marisiensis - Seria Medica Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
0.40
自引率
0.00%
发文量
0
审稿时长
24 weeks
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