Three-component coupling approach for the synthesis of 4H-pyrans and pyran-annulated heterocyclic scaffolds utilizing Ag/TiO2 nano-thin films as robust recoverable catalyst

IF 0.5 4区 化学 Q3 Pharmacology, Toxicology and Pharmaceutics
Fatemeh Noori Sadeha, M. Lashkari, Nourallah Hazeria, Maryam Fatahpoura, Malek Taher Maghsoodloua, Mohammad Saeed Hadavic, Sahar Mahnaeic
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引用次数: 0

Abstract

As a segment of ongoing surveys and with the aim of expansion of environmentally benign processes, a series of biologically varied type of substituted 2-amino-3-cyano-4 H -pyrans and pyran-annulated Scaffolds have been synthesized by tandem Knoevenagel-cyclocondensation of aldehydes, malononitrile, and C-H-activated acidic compounds in aqueous ethanol in the presence of Ag/TiO 2 nano-thin films as an eco-friendly, recyclable, and, robust catalyst at 60°C. The salient features of this protocol are mild reaction conditions, producing target compounds in high yields, short reaction times, high atom economy, eco-friendly catalyst, easy isolation of products and no column chromatographic separation. Also, it is observed that the catalyst is highly stable during the reaction and several reuse times without observable loss in catalytic performance.
以Ag/TiO2纳米薄膜为催化剂制备4h -吡喃及吡喃环杂环支架的三组分偶联方法
作为正在进行的研究的一部分,并以扩大环境友好的工艺为目的,在60°C的环境下,在Ag/ tio2纳米薄膜的存在下,通过醛、丙二腈和C-H活化的酸性化合物的串联knoevenagel -环缩合,在水乙醇中合成了一系列具有生物多样性的取代2-氨基-3-氰基-4 -H-吡喃和吡喃环支架,作为环保、可回收和强大的催化剂。该工艺具有反应条件温和、产率高、反应时间短、原子经济性高、催化剂环保、产物易于分离、无需柱层析分离等特点。此外,观察到催化剂在反应和多次重复使用中高度稳定,没有明显的催化性能损失。
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来源期刊
自引率
0.00%
发文量
1
审稿时长
4-8 weeks
期刊介绍: Indian Journal of Chemistry (Section B) is a leading monthly journal in Organic and Medicinal Chemistry started publishing from 1976. It publishes papers on organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry. Apart from full length papers, notes and communications, the journal publishes short reviews on frontline areas under the column " advances in Contemporary Research".
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