Solubility and Solution Thermodynamics of Tylosin in Pure Solvents and Mixed Solvents at Various Temperatures

Abstract

Thermodynamic data of drug is important to industrial design and industrial application. In this paper, solubility data of tylosin in pure solvents and acetone +water mixture solvents were experimentally determined from 279.75 K to 323.15 K. The experiment results indicated that solubility of tylosin in pure solvents gradually decreased and followed this order: chloroform > buty lacetate > acetonitrile > tetrahydrofuran > acetone > benzene > n-butanol > ethy lacetate > n-propanol > ethanol > methanol > water, and solubility gradually decreased with water increasing in water+acetone mixture solvents. Moreover, experimental solubility increased with temperature increasing except for water(x ≥ c