Solubility and Solution Thermodynamics of Tylosin in Pure Solvents and Mixed Solvents at Various Temperatures

Yanmin Shen, Wenju Liu, Zehua Bao, Zhanhu Guo
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引用次数: 5

Abstract

Thermodynamic data of drug is important to industrial design and industrial application. In this paper, solubility data of tylosin in pure solvents and acetone +water mixture solvents were experimentally determined from 279.75 K to 323.15 K. The experiment results indicated that solubility of tylosin in pure solvents gradually decreased and followed this order: chloroform > buty lacetate > acetonitrile > tetrahydrofuran > acetone > benzene > n-butanol > ethy lacetate > n-propanol > ethanol > methanol > water, and solubility gradually decreased with water increasing in water+acetone mixture solvents. Moreover, experimental solubility increased with temperature increasing except for water(x ≥ c
不同温度下泰洛菌素在纯溶剂和混合溶剂中的溶解度和溶液热力学
药物的热力学数据对工业设计和工业应用具有重要意义。本文在279.75 K ~ 323.15 K范围内实验测定了泰络素在纯溶剂和丙酮+水混合溶剂中的溶解度数据。实验结果表明,泰络素在纯溶剂中的溶解度逐渐降低,其溶解度依次为:氯仿>乳酸丁酯>乙腈>四氢呋喃>丙酮>苯>正丁醇>乳酸乙酯>正丙醇>乙醇>甲醇>水,在水+丙酮混合溶剂中溶解度随水的增加而逐渐降低。除水(x≥c)外,实验溶解度随温度升高而升高
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