Protective effect and potential natural antioxidant of Cayratia trifolia (L.) Domin. leaves extracts on nitrobenzene-induced hepatotoxic rats

Q4 Pharmacology, Toxicology and Pharmaceutics

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI:10.29090/psa.2022.05.22.100

Ni Putu Ermi Hikmawanti, Tuti Wiyati, M. Muis, Farah Aisyah Nurfaizah, Windy Septiani, Ryantama Indrapraja Putra

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Abstract

Cayratia trifolia leaves contain polyphenols as a natural antioxidant that can dissolve in polar solvents. This study aims to evaluate the hepatoprotective and antioxidant activity of polar extracts (ethyl acetate and 70%-ethanol) were extracted sequentially from C. trifolia leaves on male rats induced by nitrobenzene. The extracts of C. trifolia leaves were given at a dose of 200 mg.Kg -1 BW. Silymarin as a reference was given at a dose of 28.78 mg.Kg -1 BW. The extracts and Silymarin were given orally once a day for 14 days. Rats that have received ethanol extract of C. trifolia leaves showed a significant decrease in Alkaline Phosphatase (ALP), Aspartate Transaminase (AST), Alanine Transaminase (ALT), total bilirubin, and direct bilirubin. A significant decrease in malondialdehyde (MDA) levels also occurred in the rats. On histopathological examination, the extract also showed a protective effect on rat liver. Thus, it can be concluded that the sequentially extracted ethanolic extract of C. trifolia leaves has the potential as a source of natural hepatoprotective and antioxidant activity.

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三叶草的保护作用及潜在的天然抗氧化剂多明。叶提取物对硝基苯肝毒性大鼠的作用

三叶草叶含有多酚，作为一种天然抗氧化剂，可以溶解在极性溶剂中。研究三叶草叶片极性提取物(乙酸乙酯和70%乙醇)对硝基苯诱导的雄性大鼠的肝保护和抗氧化作用。给药剂量为200mg的三叶草叶提取物。Kg -1体重。水飞蓟素作为对照物，剂量为28.78 mg。Kg -1体重。提取液和水飞蓟素每天口服1次，连用14天。三叶草叶乙醇提取物对大鼠的碱性磷酸酶(ALP)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、总胆红素和直接胆红素均有显著降低。大鼠的丙二醛(MDA)水平也显著下降。组织病理学检查显示，该提取物对大鼠肝脏也有保护作用。综上所述，三叶草乙醇提取物具有一定的天然保肝和抗氧化活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutical Sciences Asia Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The Pharmaceutical Sciences Asia (PSA) journal is a double-blinded peer-reviewed journal in English published quarterly, by the Faculty of Pharmacy, Mahidol University, Thailand. The PSA journal is formerly known as Mahidol University Journal of Pharmaceutical Sciences and committed to the timely publication of innovative articles and reviews. This journal is available in both printed and electronic formats. The PSA journal aims at establishing a publishing house that is open to all. It aims to disseminate knowledge; provide a learned reference in the field; and establish channels of communication between academic and research expert, policy makers and executives in industry and investment institutions. The journal publishes research articles, review articles, and scientific commentaries on all aspects of the pharmaceutical sciences and multidisciplinary field in health professions and medicine. More specifically, the journal publishes research on all areas of pharmaceutical sciences and related disciplines: Clinical Pharmacy Drug Synthesis and Discovery Targeted-Drug Delivery Pharmaceutics Biopharmaceutical Sciences Phytopharmaceutical Sciences Pharmacology and Toxicology Pharmaceutical Chemistry Nutraceuticals and Functional Foods Natural Products Social, Economic, and Administrative Pharmacy Clinical Drug Evaluation and Drug Policy Making Antimicrobials, Resistance and Infection Control Pharmacokinetics and Pharmacodynamics.