Analyzing the Role of Arterial Spin Labelling in Patients Undergoing Endovascular Thrombectomy for Large Vessel Occlusion—a Prospective Single Center Study

Suhaila Parveen, Aiswarya Raj, N. Basheer, Paul J. Alapatt, S. Janardhanan, Abdurehiman Kp, KG Ramakrishnan
{"title":"Analyzing the Role of Arterial Spin Labelling in Patients Undergoing Endovascular Thrombectomy for Large Vessel Occlusion—a Prospective Single Center Study","authors":"Suhaila Parveen, Aiswarya Raj, N. Basheer, Paul J. Alapatt, S. Janardhanan, Abdurehiman Kp, KG Ramakrishnan","doi":"10.1177/25166085231186921","DOIUrl":null,"url":null,"abstract":"Acute stroke is one of the leading causes of death globally. Imaging remains the most common modality to diagnose and predict outcomes in patients with stroke. Conventionally, computed tomography (CT) was the preferred choice; however, imaging has expanded to include newer modalities such as Dynamic Susceptibility Contrast (DSC), Dynamic Contrast-Enhanced MRI (DCE), and Arterial Spin Labelling MRI. An alternative method of assessing perfusion, ASL uses the spins of endogenous water protons as a tracer rather than administering a contrast agent. In this manner, endogenous water in the arterial blood is labelled electromagnetically and employed as a freely diffusible tracer. ASL, as opposed to CT, DSC or DCE, allows estimation of cerebral blood flow without exposure to radiation or the administration of contrast material, which is advantageous for patients with impaired renal function or repetitive perfusion imaging. Thus a prospective study was conducted to explore the use of Arterial Spin Labelling MRI in the setting of acute ischemic stroke in both pre and post-thrombectomy patients. Our study is significant as there are no existing prospective studies comparing the cerebral perfusion measured using ASL with neurological outcomes.","PeriodicalId":93323,"journal":{"name":"Journal of stroke medicine","volume":"29 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of stroke medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/25166085231186921","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Acute stroke is one of the leading causes of death globally. Imaging remains the most common modality to diagnose and predict outcomes in patients with stroke. Conventionally, computed tomography (CT) was the preferred choice; however, imaging has expanded to include newer modalities such as Dynamic Susceptibility Contrast (DSC), Dynamic Contrast-Enhanced MRI (DCE), and Arterial Spin Labelling MRI. An alternative method of assessing perfusion, ASL uses the spins of endogenous water protons as a tracer rather than administering a contrast agent. In this manner, endogenous water in the arterial blood is labelled electromagnetically and employed as a freely diffusible tracer. ASL, as opposed to CT, DSC or DCE, allows estimation of cerebral blood flow without exposure to radiation or the administration of contrast material, which is advantageous for patients with impaired renal function or repetitive perfusion imaging. Thus a prospective study was conducted to explore the use of Arterial Spin Labelling MRI in the setting of acute ischemic stroke in both pre and post-thrombectomy patients. Our study is significant as there are no existing prospective studies comparing the cerebral perfusion measured using ASL with neurological outcomes.
分析动脉自旋标记在血管内取栓治疗大血管闭塞患者中的作用——一项前瞻性单中心研究
急性中风是全球死亡的主要原因之一。成像仍然是诊断和预测脑卒中患者预后的最常用方法。传统上,计算机断层扫描(CT)是首选;然而,成像已经扩展到包括新的模式,如动态敏感性对比(DSC),动态对比增强MRI (DCE)和动脉自旋标记MRI。一种评估灌注的替代方法,ASL使用内源性水质子的自旋作为示踪剂,而不是使用造影剂。通过这种方式,动脉血液中的内源性水被电磁标记,并被用作自由扩散的示踪剂。与CT、DSC或DCE相比,ASL可以在不暴露于辐射或给药造影剂的情况下估计脑血流量,这对肾功能受损或重复灌注成像的患者是有利的。因此,我们进行了一项前瞻性研究,探讨动脉自旋标记MRI在急性缺血性卒中患者取栓前后的应用。我们的研究具有重要意义,因为目前还没有前瞻性研究比较使用ASL测量的脑灌注与神经学结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信