Comparative study of intravenous butorphanol versus intravenous clonidine for prevention of intraoperative shivering under spinal anaesthesia

Sajidhusain B Nadaf
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Abstract

Background: Shivering is a common problem during the perioperative period, in surgeries done under regional anesthesia. Shivering is a potentially serious complication, resulting in increased metabolic rate; increased oxygen consumption along with raised carbon dioxide production; ventilation and cardiac output; adverse postoperative outcomes, such as wound infection; increased surgical bleeding; and morbid cardiac events.4,5 Present study aimed to compare the efficacy of butorphanol versus clonidine for control of shivering in patients undergoing surgeries under spinal anaesthesia. Material and Methods: Present study was conducted patients aged between 18-60 years, of either sex, ASA physical status I/II, scheduled for elective lower abdominal surgeries under subarachnoid block. 60 Patients were randomly allocated using a computer generated table of random numbers. Group B (n= 30) received intravenous bolus butorphanol 1 mg while group C (n= 30) received an intravenous bolus of 150 μg (1 mL) clonidine. Results: In present study, 60 patients were randomly allocated into group B (n= 30, received butorphanol) and group C (n= 30, received clonidine). Age (years), weight (Kg), BMI(Kg/m2), Gender (Male/Female), ASA grade, duration of surgery (min) and baseline axillary temperature were comparable between both groups and no statistically significant difference was noted among them. In butorphanol group an earlier onset of sensory as well as motor block and prolonged duration of sensory as well as motor block was noted as compared to clonidine group and difference was statistically significant. In present study, higher incidence of shivering was noted in clonidine group as compared to butorphanol group and difference was statistically significant. Side effects, such as hypotension, nausea and vomiting werer more in clonidine group as compared to butorphanol group and difference was statistically significant. Bradycardia was noted in both groups in 3 patients. Conclusion: Intravenous butorphanol is a safe and effective for prevention of shivering as well as had early onset and prolonged duration of sensory/motor block.
布托啡诺与可乐定预防脊髓麻醉术中寒战的比较研究
背景:在区域麻醉下进行的手术中,寒战是围手术期的常见问题。颤抖是一种潜在的严重并发症,会导致代谢率增加;氧气消耗增加,二氧化碳产量增加;通气和心输出量;术后不良后果,如伤口感染;手术出血增多;以及病态的心脏事件。4,5本研究旨在比较布托啡诺与可乐定对脊柱麻醉手术患者控制寒战的疗效。材料与方法:本研究纳入年龄在18-60岁,男女不限,ASA身体状态I/II,计划在蛛网膜下腔阻滞下择期下腹部手术的患者。60名患者使用计算机生成的随机数表随机分配。B组(n= 30)静脉滴注布托啡诺1 mg, C组(n= 30)静脉滴注可乐定150 μg (1 mL)。结果:本研究将60例患者随机分为B组(n= 30,给予布托啡诺)和C组(n= 30,给予可乐定)。两组患者年龄(岁)、体重(Kg)、BMI(Kg/m2)、性别(男/女)、ASA分级、手术时间(min)、基线腋窝温度具有可比性,两组间差异无统计学意义。与可乐定组相比,布托啡诺组感觉和运动阻滞的发病时间更早,感觉和运动阻滞的持续时间更长,差异有统计学意义。本研究中,可乐定组的寒战发生率高于布托啡诺组,差异有统计学意义。与布托啡诺组相比,可乐定组出现低血压、恶心、呕吐等不良反应较多,差异有统计学意义。两组均有3例患者出现心动过缓。结论:静脉注射布托啡诺预防寒战安全有效,且感觉/运动阻滞早起,持续时间长。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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