Study of clinical profile, laboratory parameters and outcomes of COVID-19 Patients in a Tertiary Care Centre in North India

Abstract

Introduction: The coronavirus disease 2019 (COVID-19) pandemic has rapidly spread to many countries around the world and is still spreading due to newer variants. The clinico-hematological characteristics of COVID-19 have been reported from different countries but only a few large-scale studies have been conducted in India. This study aims to describe the clinical-laboratory data and outcome of COVID-19 patients admitted to tertiary care COVID center in North India. Method: This is a cross-sectional observational study. Data were collected from the medical records department regarding the epidemiological parameters, comorbidities, symptoms, laboratory parameters, and outcomes of patients with the COVID-19 disease admitted to our hospital over 4 months. The follow-up of the laboratory parameters (in a subset of patients) was also evaluated. Result: The mean age of the patients was 46.5 years with a male preponderance (male: female ratio: 2:1). The comorbidities were present in 103 (60.6%) patients, of which diabetes mellitus (n = 65; 38.2%) was the most common. A significant proportion of the patients were symptomatic (n = 148; 87.1%); the most common symptom being fever followed by dyspnea in 65 and 60% of the patients. Anemia was present in 36.5% of the patients, leukocytosis in 15.3% of the patients while lymphopenia was noted in 41.2% of the patients; 12.9% of the patients had thrombocytopenia. A majority of the patients were managed with supportive treatment. Seventy-five (46.5%) patients required oxygen supplementation and 29 (17%) patients had severe disease. Mortality occurred in 20 (11.8%) patients. Conclusion: In this single-center study of hospitalized COVID-19 patients, most of the patients were symptomatic having comorbidities. The most common symptoms were fever and shortness of breath. Many patients had lymphopenia and neutrophilia.