The Effect of Corncob (Zea mays) Extract Cream on the Number of Melanin Pigments of Guinea Pig Exposed to Ultraviolet

Berkala Ilmu Kesehatan Kulit dan Kelamin Pub Date : 2021-11-30 DOI:10.20473/bikk.v33.3.2021.194-199

Pasid Harlisa, Sita Mahardika, Suryani Yuliyanti

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Abstract

Background: Exposure to Ultraviolet B (UVB) rays on the skin causesmany problems, including pigmentation and aging effect. Hence, protection against it is needed. Purpose: The study aimedto determine the effect of corncob extract cream on the number of melanin pigments in guinea pig skins exposed to UVB rays. Methods: Anexperimental post-test-only control group study was conducted on the 25 guinea pigs. The guinea pigs were divided randomly into five groups: group I without cream, group II cream base, group III hydroquinone cream, group IV 30% corncob extract cream, and group V 40% corncob extract cream. The cream was given daily for 20 minutes before UVB exposure and 4 hours after UVB exposure. The total dose of UVB exposure was 780 mJ / cm2 for 28 days. The amount of melanin pigment was calculated using the CX21 image J. Result: The number of melanin pigment in groups I, II, III, IV, and V were 22.8±0.4 cells, 18±0.3 cells, 6.3±3.1 cells, 13.8±0.2 cells, and 9.4±0.5 cells, respectively. Asignificantlydifferent value of One way ANOVA test was <0.05. Thus, there was a difference in the number of melanin pigments between the five groups. LSD post-hoc test showed differences in each group (p <0.05). Conclusion: 40% corn cobs extract cream effectively decreased the number of melanin pigment in guinea pigs exposed to UVB rays.

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玉米芯提取物乳霜对紫外线照射豚鼠黑色素数量的影响

背景:皮肤暴露在紫外线B (UVB)射线下会导致许多问题，包括色素沉着和衰老效应。因此，需要对其进行保护。目的:研究玉米芯提取物乳膏对UVB照射豚鼠皮肤中黑色素数量的影响。方法:以25只豚鼠为实验对象，进行单纯后试对照组研究。将豚鼠随机分为5组:不加奶油组、奶油底组、对苯二酚组、30%玉米芯提取膏组、40%玉米芯提取膏组。在中波紫外线照射前20分钟，在中波紫外线照射后4小时，每天使用这种乳霜。UVB照射28天总剂量为780 mJ / cm2。结果:I、II、III、IV、V组黑色素数量分别为22.8±0.4个细胞、18±0.3个细胞、6.3±3.1个细胞、13.8±0.2个细胞、9.4±0.5个细胞。单因素方差分析差异有统计学意义<0.05。因此，五组之间的黑色素数量是不同的。LSD事后检验各组差异有统计学意义(p <0.05)。结论:40%玉米芯提取物乳膏能有效降低UVB照射豚鼠体内黑色素的数量。

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Berkala Ilmu Kesehatan Kulit dan Kelamin

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