Wayne Alexander, K. Bernstein, K. Catt, M. de Gasparo, Khuraijam Dhanachandra Singh, S. Eguchi, E. Escher, T. Goodfriend, M. Horiuchi, L. Hunyady, A. Husain, T. Inagami, S. Karnik, Jacqueline R. Kemp, W. Thomas, P. Timmermans, Kalyan C. Tirupula, Hamiyet Unal, T. Unger, P. Vanderheyden
{"title":"Angiotensin receptors in GtoPdb v.2023.1","authors":"Wayne Alexander, K. Bernstein, K. Catt, M. de Gasparo, Khuraijam Dhanachandra Singh, S. Eguchi, E. Escher, T. Goodfriend, M. Horiuchi, L. Hunyady, A. Husain, T. Inagami, S. Karnik, Jacqueline R. Kemp, W. Thomas, P. Timmermans, Kalyan C. Tirupula, Hamiyet Unal, T. Unger, P. Vanderheyden","doi":"10.2218/gtopdb/f6/2023.1","DOIUrl":null,"url":null,"abstract":"The actions of angiotensin II (Ang II) are mediated by AT1 and AT2 receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Angiotensin receptors [63, 155]), which have around 30% sequence similarity. The decapeptide angiotensin I, the octapeptide angiotensin II and the heptapeptide angiotensin III are endogenous ligands. losartan, candesartan, olmesartan, telmisartan, etc. are clinically used AT1 receptor blockers.","PeriodicalId":14617,"journal":{"name":"IUPHAR/BPS Guide to Pharmacology CITE","volume":"13 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IUPHAR/BPS Guide to Pharmacology CITE","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2218/gtopdb/f6/2023.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The actions of angiotensin II (Ang II) are mediated by AT1 and AT2 receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Angiotensin receptors [63, 155]), which have around 30% sequence similarity. The decapeptide angiotensin I, the octapeptide angiotensin II and the heptapeptide angiotensin III are endogenous ligands. losartan, candesartan, olmesartan, telmisartan, etc. are clinically used AT1 receptor blockers.
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