Amidoalkyl Naphthols: Trifluoroacetic Acid (TFA) Catalyzed One-Pot, Multi-Component Synthesis

Journal of Applied Solution Chemistry and Modeling Pub Date : 2013-11-25 DOI:10.6000/1929-5030.2013.02.04.8

Vinay S. Kadam, Priyanka Khanvilkar, Arun L. Patel

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Abstract

Trifluoroacetic acid (TFA) was found as an efficient catalyst for the synthesis of amidoalkyl naphthols from aromatic aldehydes, β-naphthol and acetamide/benzamide under solvent free condition at 80 o C. All the synthesized compounds were characterized by IR, 1 H NMR and Mass spectra. The advantages of the new method were good yields, short reaction times, simple work-up, inexpensive and easily available catalyst and economical due to absence of solvent. Therefore, this method could be an attractive alternative to existing methods for the synthesis of biologically important amidoalkyl naphthols. Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;}

查看原文本刊更多论文

氨基烷基萘酚:三氟乙酸催化一锅多组分合成

在80℃无溶剂条件下，发现三氟乙酸(TFA)是芳香族醛、β-萘酚和乙酰胺/苯酰胺合成氨基烷基萘酚的有效催化剂。所得化合物经IR、1h NMR和质谱表征。该方法具有收率高、反应时间短、工序简单、催化剂便宜易得、无需溶剂等优点。因此，该方法可以替代现有的合成具有重要生物学意义的酰胺烷基萘酚的方法。正常0 false false false EN-US X-NONE X-NONE /*样式定义*/表。mso-style-name:"Table Normal";mso-tstyle-rowband-size: 0;mso-tstyle-colband-size: 0;mso-style-noshow:是的;mso-style-priority: 99;mso-style-qformat:是的;mso-style-parent:“”;mso- font - family:宋体;mso-para-margin-top: 0;mso-para-margin-right: 0;mso-para-margin-bottom: 10.0分;mso-para-margin-left: 0;行高:115%;mso-pagination: widow-orphan;字体大小:11.0分;字体类型:“Calibri”、“无衬线”;mso-ascii-font-family: Calibri;mso-ascii-theme-font: minor-latin;mso-fareast-font-family:宋体;mso-fareast-theme-font: minor-fareast;mso-hansi-font-family: Calibri;mso-hansi-theme-font: minor-latin;}

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Journal of Applied Solution Chemistry and Modeling

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