Study on Reproductive Disorders in Patients with Metabolic Syndrome and Obesity: Pathogenesis, Clinical Manifestations and Prevention

Abstract

The metabolic syndrome (MetS) increase prevalence leads to the growing attention of medical scientists. Studying the aetiology, consequences and prevention of MetS is necessary to improve medical care for patients with this disease and is also an important social issue. The purpose of the study is to light the basic reasons for the development of reproductive disorders in patients with metabolic syndrome and lifestyle role in the prevention of negative reproductive events. Methods: Contextual searches were performed in Cochrane Library, PubMed as well as WHO recommendations and leading European and American associations on the management of patients with Mets. Inclusion criteria were both review articles and single studies reporting the analysis of modern ideas about the pathogenesis of reproductive health in patients with Mets. Results: The issues of pathogenesis, clinical manifestations, outcomes and prevention of reproductive disorders and infertility in patients with MetS and obesity studied. It was found that the main reproductive disorders of men with MetS were decreased testosterone levels, decreased sperm fertility and erectile dysfunction. In women with MetS, metabolic disorders also lead to reproductive disorders such as infertility, menstrual irregularities, premature birth, births of children with congenital anomalies. Conclusions: Reproductive disorders in patients with MetS can have negative consequences for individuals as reduced quality of life, depression and increasing metabolic disorders, and for the countries as depopulation. Normalization of basal metabolic rate by exercise and a diet improves reproductive health in patients with MetS. However, despite the proven positive impact of lifestyle adjustment, the search for the best treatment for reproductive disorders of patients with MetS remains open.