Effect of subchronic use of sodium nitrite on the functional parameters of an isolated rat heart

D. S. Laptev, S. Petunov, O. V. Nechaykina, Dmitriy Vladimirovich Bobkov
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Abstract

Introduction. The active development of agriculture with the widespread use of nitrogen-containing fertilizers, increased consumption of processed meat products containing sodium nitrite as a preservative, inevitably leads to an increase in the nitrogen load on the human body and can cause the development of cardiovascular diseases. Materials and methods. The cardiotoxic effect of sodium nitrite was evaluated on a model of an isolated rat heart with subchronic intragastric administration for 28 days at doses of 0.03; 0.3; 3.0 mg/kg. Results. The use of sodium nitrite leads to dilation of the coronary vessels and myocardium, inhibition of the contractile activity of the heart, disruption of its electrical activity in the form of a shortening of the QT interval associated with an increased risk of ventricular fibrillation, and a tendency to increase the amplitude of the T wave, which indicates myocardial ischemia. In a stress test with total ischemia, it was revealed that the magnitude of the change in the parameters characterizing the restoration of myocardial function under reperfusion conditions is inversely proportional to the dose of sodium nitrite used. Limitations. The study was performed only on male white rats more prone to the development of cardiovascular pathology. Conclusion. With subchronic administration, sodium nitrite has cardiotoxicity at a dose of 0.028 mg/kg, which is twice lower than the WHO-established permissible daily intake for humans (0.06 mg/kg).
亚硝酸钠对离体大鼠心脏功能参数的影响
介绍。随着含氮肥料的广泛使用,农业的积极发展,含有亚硝酸钠作为防腐剂的加工肉制品的消费量增加,不可避免地导致人体氮负荷的增加,并可能导致心血管疾病的发展。材料和方法。在离体大鼠心脏模型上,以0.03剂量亚硝酸钠亚慢性灌胃给药28天,评估其心脏毒性作用;0.3;3.0毫克/公斤。结果。亚硝酸钠的使用导致冠状血管和心肌的扩张,抑制心脏的收缩活动,以QT间期缩短的形式破坏其电活动,这与心室颤动的风险增加有关,并倾向于增加T波的振幅,这表明心肌缺血。在全缺血的应激试验中,我们发现在再灌注条件下表征心肌功能恢复的参数的变化幅度与使用亚硝酸钠的剂量成反比。的局限性。这项研究只在更容易发生心血管疾病的雄性白鼠身上进行。结论。亚慢性给药时,剂量为0.028 mg/kg的亚硝酸钠具有心脏毒性,比世卫组织确定的人类每日允许摄入量(0.06 mg/kg)低两倍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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