Sorption Composite Based on Hydroxyapatite and Biopolymers for Drainage of Purulent Cavities

Abstract

In this work, we describe a novel negative pressure drainage system based on the use of sorption material on a perforated silicone. The chemical composition of the sorption material includes inorganic (HA, ZnO) and organic (CS, Alg, glutaraldehyde, glycerin) components. The applied technology of ionotropic crosslinking and sublimation and the chemical composition of the material gives the material shape stability and allows control of the degree of swelling and porosity. The additional introduction of the antibiotic Ceftriaxone and agents with antimicrobial action (chitosan, zinc oxide) inhibit bacterial cells in conditions of advanced peritonitis. The composite material is hydrophilic. Its degree of swelling, which characterizes sorption capacity, is 240-380%, depending on the chemical composition. In vivo studies show that due to the sorption properties of HA and organic components, the created drainage system reduces the exudation phase, exhibits detoxification and antibacterial properties. Drainage can be used in surgery for the treatment of purulent - necrotic foci of various origins.