Synthesis, Characterization, and Biological Activity of 5-Phenyl-1,3,4-thiadiazole-2-amine Incorporated Azo Dye Derivatives

C. T. K. Kumar, J. Keshavayya, Tantry N. Rajesh, S. K. Peethambar, Angadi R. Shoukat Ali
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引用次数: 38

Abstract

5-Phenyl-1,3,4-thiadiazole-2-amine has been synthesized by single step reaction. A series of heterocyclic azodyes were synthesized by diazotisation of 5-phenyl-1,3,4-thiadiazole-2-amine by nitrosyl sulphuric acid followed by coupling with different coupling compounds such as 8-hydroxyquinoline, 2,6-diaminopyridine, 2-naphthol, N,N-dimethyl aniline, resorcinol, and 4,6-dihydroxypyrimidine. The dyes were characterized by UV-Vis, IR, 1H-NMR, 13C NMR, and elemental analysis. The synthesized compounds were also screened for biological activity.
5-苯基-1,3,4-噻二唑-2-胺偶氮染料衍生物的合成、表征和生物活性
采用一步法合成了5-苯基-1,3,4-噻二唑-2-胺。用亚硝基硫酸将5-苯基-1,3,4-噻二唑-2-胺重氮化,然后与8-羟基喹啉、2,6-二氨基吡啶、2-萘酚、N,N-二甲基苯胺、间苯二酚、4,6-二羟基嘧啶等偶联化合物偶联,合成了一系列杂环偶氮化合物。通过紫外可见光谱、红外光谱、核磁共振氢谱、核磁共振13C谱和元素分析对染料进行了表征。并对合成的化合物进行了生物活性筛选。
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