PREVENTIVE EFFECT OF SOME FLAVONOIDS ON THE ASSIMILATION OF CARBOHYDRATES IN RATS

Abstract

Acute pancreatitis today is a progressively spreading disease, for which preventive and corrective preparations have not yet been developed. The purpose of the research is to study the preventive effect of certain flavonoids on the assimilation of carbohydrates in acute pancreatitis. Acute pancreatitis was induced by two intraperitoneal injections of L-arginine (100 mg/kg) to rats with an interval of two hours. It turned out that in rats with induced acute pancreatitis, there was an increase in the serum α-amylase activity and glucose level, along with a decrease in α-amylase activity in the intestinal contents, maltase activity in the small intestine mucosa, and glycogen content in the liver. Double administration of rutin, dihydroquercetin, pulicarone, and tamiflazid at a dose of 50 mg/kg/24 h two days before the induction of acute pancreatitis prevented pancreatitis-induced shifts in carbohydrate assimilation in the small intestine cavity and blood glucose level and α-amylase activity. The preventive effect in the development of pancreatitis for rutin and dihydroquercetin was more pronounced than for pulicarone and tamiflazid. Therefore, the introduction of flavonoids helps to prevent the development of pancreatitis, as well as concomitant negative changes in cavity and membrane hydrolysis and carbohydrate metabolism.