Association of Dementia in Ischemic Stroke: A Case Control Study

Abu Jafor Md Salahuddin, M. R. K. Khan, Md Muniruzzaman Bhuiyan, Nuruddin Md Eusuf, Rased Imam Zahid, K. Patwary, M. Salahuddin, Md Sayeed Hassan, Md Abdul Alim, S. Majumder, M. Rana
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Abstract

Objectives: To evaluate the association of dementia in ischemic stroke. Methodology: This case control study was carried out in the department of Neurology at BSMMU, Dhaka from 1st January 2010 to 31st December 2011 for duration of two years to evaluate the association of dementia in ischemic stroke. The target population for this study include all patients presented with ischemic stroke at the range of 3 to 6 months after stroke with the age group of 40 to 70 years are included in this study and patients of dementia other than ischemic stroke like Alzhiemer’s disease, vit-B12 deficiency, thyroid dysfunction were excluded from this study. A total number of 120 respondents were included in this study. Age & sex matched 60 patients of ischemic stroke were selected as cases and rest 60 people were taken as control group. Informed written consent was taken from each patient or his/ her attendant. All information regarding history and physical findings; and other risk factors for dementia were collected to fill up the preformed questionnaire. Relevant physical examinations like nervous system examination, selected general and systemic examination were recorded. Result & Observation: Dementia was present in case and control group 18(30.0%) and 2(3.3%) respectively. The difference was statistically significant (p=0.001). Present smoking habit was more in case (45.0%) than in control group (16.7%) which was statistically significant (p=0.001) with a OR of 4.07 with a 95% CI of 1.89-8.75. Past smoking habit was more in case (16.7%) than control group (11.7%). Non-smoker was more in control (71.7%) than case group (38.3%). Diabetes mellitus was more common in case group (38.3%) than control group 5(8.3%) which was statistically significant (p=0.001) with a 6.84 OR and 95% CI of 2.39-19.6. Conclusion: The study permit to conclude that dementia is directly associated with ischemic stroke. We found a correlation between age, family history of dementia, hypertension, diabetes mellitus and dyslipidemia with dementia. Bangladesh Journal of Neuroscience 2014; Vol. 30 (1): 35-44
缺血性脑卒中与痴呆的关系:一项病例对照研究
目的:探讨痴呆与缺血性脑卒中的关系。方法:本病例对照研究于2010年1月1日至2011年12月31日在达卡BSMMU神经内科进行,为期两年,以评估痴呆与缺血性卒中的关系。本研究的目标人群包括脑卒中后3 ~ 6个月出现缺血性脑卒中的所有患者,年龄在40 ~ 70岁,排除阿尔茨海默病、维生素b12缺乏症、甲状腺功能障碍等缺血性脑卒中以外的痴呆患者。本研究共纳入120名受访者。选取年龄、性别相匹配的缺血性脑卒中患者60例为病例,其余60例为对照组。从每位患者或其护理人员处取得知情书面同意。有关病史和物理检查结果的所有信息;并收集痴呆的其他危险因素来填写预先编制的问卷。记录相关的身体检查,如神经系统检查、选定的全身检查和全身检查。结果与观察:痴呆患者18例(30.0%),对照组2例(3.3%)。差异有统计学意义(p=0.001)。有吸烟习惯的患者(45.0%)多于对照组(16.7%),差异有统计学意义(p=0.001), OR为4.07,95% CI为1.89 ~ 8.75。有吸烟史者(16.7%)高于对照组(11.7%)。非吸烟者控制组(71.7%)高于病例组(38.3%)。病例组糖尿病发生率(38.3%)高于对照组(8.3%),差异有统计学意义(p=0.001), OR为6.84,95% CI为2.39 ~ 19.6。结论:本研究证实痴呆与缺血性脑卒中有直接关系。我们发现年龄、痴呆家族史、高血压、糖尿病和血脂异常与痴呆之间存在相关性。孟加拉国神经科学杂志2014;Vol. 30 (1): 35-44
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