Improved Oral Bioavailability and Variability Control in Pharmacokinetic Data – Role of Formulations

Abstract

In order to render the best possible outcome for effective in vivo human translatability of the preclinical efficacy measures for orally administered drugs certain clinical pharmacology attributes play a key role. In this regard, effective and predictable absorption is the most relevant one; followed by controlled and reasonable variability in the pharmacokinetic parameters. Hence oral bioavailability would be expected to play a vital role in delivering the drug to site(s) of action needed to attain the desired efficacy measures.