Pemanfaatan Ekstrak Jintan Hitam Untuk Menurunkan Kadar Enzim Lp-Pla2 Sebagai Kandidat Pengobatan Aterosklerosis

Abstract

Ox-LDL deposits in the sub-endothelial easily occur in individuals who have hyperlipidemia accompanied with oxidative stress. The enzyme Lp-PLA2 is an enzyme marker of three proaterogenik conditions, those are hyperlipidemia, oxidative stress andinflammation. Black cumin seeds (Nigella sativa L.) have antioxidants ingredient that can inhibit lipid peroxidation, and expected toinhibit atherosclerosis through decreased levels of the enzyme Lp-PLA2 and F2-Isp. This study used posttest only control group designusing experimental animals Rattusnorvegicus Wistar males. The study analysed the number of foam cells, lipid profi le, Lp-PLA2 andF2-Isp plasma levels in hyperlipidemia rats were given extracts of black cumin seeds with 3 different doses (0; 3.6 and 7.2 mg / kg). The results showed that the extract of black cumin seeds can decrease serum levels of Lp-PLA2, tend to reduce the formation of foam cells,but not significant to decreasing levels of F2-Isp. Black cumin seeds extract can decrease cholesterol, TG, LDL and increase HDL inthe blood serum. The extract of black cumin seeds is anti atherogenic by reducing the enzyme Lp-PLA2 and improve lipid profiles.