Prevalence of Concomitant Bacteria among malaria Patients attending Government Hospitals in Ondo State, South-West Nigeria

安徽医药 Pub Date : 2023-03-31 DOI:10.55940/medphar202316

K. Ajayi, F. Omoya, M. Oladunmoye, B. Oladejo

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引用次数: 2

Abstract

Background:Patients suffering from severe malaria have an increased risk of co-occurring bacterial sepsis, which results in higher mortality rates than malaria alone. Concomitant bacterial infections can worsen malaria symptoms, leading to increased illness and death rates. This study aimed to investigate the relationship between malaria and concomitant bacteremia among patients in Ondo State, Nigeria.Aim: The study's objective was to determine the prevalence of bacterial concomitant among malaria patients and assess the relationship between malaria and bacteremia in the study population.Material and Methods: A cross-sectional study was conducted among feverish individuals in certain Ondo State government hospitals. One milliliter of blood was collected from malaria-positive patients, confirmed using microscopic examination of Giemsa-stained thick and thin blood films, and an Malaria rapid diagnostic tests (RDT) kit was cultured for bacterial enumeration. The collected data were statistically analyzed using Chi-square and correlation tests, with a 𝑃value <0.05 considered significant.Result: The study found a concomitant bacteria prevalence of 19.95% (85/426), with a significant (P= <0.001, r = 0.00334) positive correlation between malaria and bacterial concomitant.Age was significantly (p = 0.072, df= 18, χ2 = 27.389) associated with bacterial concomitant, and the mean bacterial count was 9.71±1.481 cfu/ml x 107. Furthermore, level of education, marital status and tribe also significantly (p<0.05) contributed to the prevalence of concomitant bacteria.Conclusion: Our research concludes that malaria may increase the risk of bacteremia, and a significant association between malaria and concomitant bacterial infection exists. However, the reasons for bacteria's abilityto invade and thrive in the bloodstream vary. The study's findings suggest that interventions are needed to address the high prevalence of concomitant bacterial infections among malaria patients in the study area.

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在尼日利亚西南部翁多州政府医院就诊的疟疾患者中伴随菌的流行情况

背景:患有严重疟疾的患者同时发生细菌性败血症的风险增加，其导致的死亡率高于单独的疟疾。伴随的细菌感染可使疟疾症状恶化，导致发病率和死亡率增加。本研究旨在调查尼日利亚翁多州患者中疟疾和伴随菌血症之间的关系。目的:该研究的目的是确定疟疾患者中细菌伴发的患病率，并评估研究人群中疟疾和菌血症之间的关系。材料和方法:在某些翁多州政府医院的发烧个体中进行了横断面研究。从疟疾阳性患者身上采集了1毫升血液，通过吉姆萨染色的厚薄血膜的显微镜检查予以确认，并培养了疟疾快速诊断测试(RDT)试剂盒用于细菌计数。收集的资料采用卡方检验和相关检验进行统计学分析，以𝑃value <0.05为差异有统计学意义。结果:研究发现伴发细菌患病率为19.95%(85/426)，疟疾与伴发细菌呈正相关(P= <0.001, r = 0.00334)。年龄与细菌伴发有显著相关性(p = 0.072, df= 18， χ2 = 27.389)，平均细菌计数为9.71±1.481 cfu/ml × 107。此外，文化程度、婚姻状况和部落对伴随菌的流行也有显著影响(p<0.05)。结论:我们的研究表明，疟疾可能增加菌血症的风险，并且疟疾与伴随的细菌感染之间存在显著的关联。然而，细菌在血液中入侵和繁殖的原因各不相同。这项研究的发现表明，需要采取干预措施来解决研究地区疟疾患者中伴随细菌感染的高流行率。

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来源期刊

安徽医药

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14800

期刊介绍： Anhui Medical and Pharmaceutical Journal is an academic journal. It is an academic journal under the supervision of Anhui Provincial Drug Administration and sponsored by Provincial Pharmaceutical Society, mainly reporting the academic papers and important information on the progress of international medical research, clinical pharmacy, drug monitoring, and drug production and management. It has columns such as PiYou comment and discussion, pharmacy research, pharmacy and clinical, drug analysis, drug management, pharmaceutical industry, pharmacy dynamics, hospital pharmacy, pharmacy, computer applications and so on. Journal for medicine, health care, drug supervision workers; pharmaceutical production and management of science and technology, management personnel. It is a professional, practical, scientific and technological strong periodical.