Progress of cystic fibrosis

Abstract

Cystic fibrosis (CF) is an autosomal recessive hereditary disease with a low incidence in Asia.There are no epidemiological statistics on the incidence of CF in China.CF can lead to dysfunction in multi-system of the whole body.As a safe, fast and easy method, gene detection is becoming more and more important in CF diagnosis.However, the gene mutation spectrum of Chinese population has not yet been proposed.Multidisciplinary combination therapy and gene therapy are the new directions of CF study.At present, there are no guidelines and disease management suitable for the Chinese population.This article reviews the current situation, pathogenesis, clinical manifestations, gene diagnosis and treatment in China. Key words: Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Sweat chloride test; Gene diagnosis