Occurrence of Acute Myeloid Leukemia in Young Pregnant Women

IF 3 Q2 Medicine
J. Menezes, M. Emerenciano, F. Pimenta, Gilson Guedes Filho, I. Magalhães, M. Sant'ana, Marina Lipkin Vasquez, Llana Zalcberg Renault, M. Pombo-de-Oliveira
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引用次数: 5

Abstract

Although acute leukaemia is rare in pregnancy its importance lies in its life-threatening potential, both to the child and the mother. The possibility of vertical transmission of leukemic cells increases the attention devoted to these patients and their offspring. Three cases of pregnant young women (15-17 years of age) with AML are presented. This series of cases is the first report where gene abnormalities such as ITD mutations of the FLT3 gene and AML1/ETO fusion genes were screened in pregnant AML patients and their babies, so far. Unfortunately, very poor outcomes have been associated to similar cases described in literature, and the same was true to the patients described herein. Although very speculative, we think that the timing and possible similar exposures would be involved in all cases.
年轻孕妇急性髓性白血病的发生
虽然急性白血病在怀孕期间很少见,但它的重要性在于它对孩子和母亲都有可能危及生命。白血病细胞垂直传播的可能性增加了对这些患者及其后代的关注。本文报道3例年轻孕妇(15-17岁)急性髓性白血病。这一系列病例是迄今为止首次在妊娠AML患者及其婴儿中筛查FLT3基因ITD突变和AML1/ETO融合基因等基因异常的报道。不幸的是,文献中描述的类似病例的预后非常差,本文所描述的患者也是如此。尽管这只是推测性的,但我们认为,所有案例都会涉及到时机和可能的类似风险敞口。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.70
自引率
0.00%
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0
审稿时长
8 weeks
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