A cross-sectional survey of cervical human papillomavirus infection in family of esophageal cancer patients

Abstract

Objective To understand the cervical human papillomavirus (HPV)infection of women in the family of esophageal cancer patients, and preliminarily explore the relationship between the cervical HPV infection and esophageal cancer. Methods The 300 female esophageal cancer patients or first-degree relatives of esophageal cancer patients in the high incidence area of esophageal cancer in Henan Province were selected, and they were examined for free cervical cancer screening. Another 300 healthy females who underwent cervical cancer screening in the First Affiliated Hospital of Zhengzhou University during the same period. A cross-sectional controlled study was performed to analyze the results of cervical cancer screening. Results The age of 300 female esophageal cancer patients or the first-degree relatives of esophageal cancer patients in the high incidence area of esophageal cancer in henan province was 24-73 years old and the median age was 47 years old, of which HPV infection rate was 18.0%(54/300), it was slightly higher than that in healthy women (14.0%, 42/300), but the difference was not significant (χ2=1.786, P=0.181). The thinprep cytologic test(TCT)results of female esophageal cancer patients or their first-degree female relatives showed that theproportion of patients with cervical lesions (2.0%, 6/300) compared with those of abnormal in health checkups (3.0%, 9/300), there was no significant difference (χ2=0.615, P=0.433). Conclusions The infection rate of cervical HPV in the family of esophageal cancer patients is slightly higher than that in the general population, so we should be paid attention to the primary prevention, providing certain basis for future research on the relationship between esophageal cancer and cervical cancer. Key words: Human papillomavirus; Esophageal cancer; Cervical cancer