Evaluation of the origins of the selectivity of polymers imprinted with a HIV protease inhibitor using infrared spectroscopy and high performance liquid chromatography.

Enantiomer Pub Date : 2002-03-01 DOI:10.1080/10242430212193
T. O'brien, N. Grinberg, G. Bicker, J. Wyvratt, N. Snow
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引用次数: 6

Abstract

This work investigates the origins of enantioselectivity of polymers imprinted with the HIV protease inhibitor, Indinavir. For the preparation of imprints of the drug, the critical interactions between the functional monomer, methacrylic acid, and Indinavir were characterized by infrared (IR) spectroscopy to explore the optimum functional monomer concentration for the polymerization. It was shown that a polymer with high selectivity and minimum non-selective binding for Indinavir was obtained when prepared with enough functional monomer to hydrogen bond with all of the functional groups of the drug without using an excess of monomer. This observation is explained in terms of a balance that is achieved in the monomer-template equilibrium during the polymerization that yields a polymer with highly selective sites and minimal non-selective sites. This paper further demonstrates that IR spectroscopy can be a valuable tool in the design and syntheses of molecular imprinted polymers.
利用红外光谱和高效液相色谱法评价HIV蛋白酶抑制剂印迹聚合物选择性的来源。
这项工作调查了印有HIV蛋白酶抑制剂Indinavir的聚合物对映体选择性的起源。为了制备该药物的印迹,利用红外光谱对功能单体、甲基丙烯酸和茚那韦之间的关键相互作用进行了表征,以探索聚合的最佳功能单体浓度。结果表明,当使用足够的功能单体与药物的所有官能团形成氢键而不使用过量的单体时,可以获得对茚那韦具有高选择性和最小非选择性结合的聚合物。这一观察结果的解释是,在聚合过程中,单体-模板平衡达到了一种平衡,这种平衡产生了具有高选择性位点和最小非选择性位点的聚合物。本文进一步证明了红外光谱在分子印迹聚合物的设计和合成中是一种有价值的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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