Available methods to enhance regenerative potential of plastic materials for bone defects replacement in orthopedics. Part 2. Use of autologous human platelet lysate

A. M. Fayn, A. Vaza, S. Gnetetskiy, K. I. Skuratovskaya, V. B. Bondarev, Yu. A. Bogolyubskiy, R. Titov, A. Sergeev
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Abstract

In the previous article, we talked about the use of platelet-rich plasma. One of the promising ways to stimulate the processes of repair and regeneration in the tissues of the damaged organ in different types of pathology is the use of platelet-rich plasma lysate. This part of the literature review covers the mechanism of action of platelet-rich plasma lysate, indications and contraindications for its use, describes the results of treatment when platelet-rich plasma lysate is used to stimulate osteogenesis. The preparation technology provides for the removal of all cellular components from the plasma, so it becomes possible to store the obtained graft for a long time. The procedure for the preparation of platelet lysate allows the simultaneous isolation of all growth factors from the cells, since the platelet lysis occurs. Lysate of platelet concentrates can be considered as a preparation that contains a complete set of stimulating growth factors. Under the influence of the lysate, the proliferation of latent osteoblasts is resumed, the signaling pathways of angiogenesis are activated, the secretion of the factors accelerating angiogenesis is stimulated, the differentiation of osteoblasts and the formation of bone tissue are triggered. The aim of this article is to summarize the results of treatment using autologous platelet lysate to improve bone regenerative potential in orthopaedics. In a final article, we shall look at the ways to use autologous red bone marrow.
提高骨科骨缺损置换塑料材料再生潜力的可行方法。第2部分。使用自体人血小板裂解液
在上一篇文章中,我们谈到了富血小板血浆的使用。在不同类型的病理中,刺激受损器官组织的修复和再生过程的有希望的方法之一是使用富含血小板的血浆裂解液。这部分文献综述涵盖了富血小板血浆裂解液的作用机制、使用适应症和禁忌症,描述了富血小板血浆裂解液刺激成骨的治疗结果。该制备技术提供了从血浆中去除所有细胞成分,因此可以长时间储存获得的移植物。制备血小板裂解液的程序允许从细胞中同时分离所有生长因子,因为血小板裂解发生了。血小板浓缩物的裂解物可以被认为是一种含有一整套刺激生长因子的制剂。在裂解液的作用下,恢复潜伏成骨细胞的增殖,激活血管生成的信号通路,刺激促血管生成因子的分泌,触发成骨细胞的分化和骨组织的形成。本文的目的是总结利用自体血小板裂解液提高骨科骨再生潜力的治疗结果。在最后一篇文章中,我们将探讨使用自体红骨髓的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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