Computational Prediction and Analysis of Interaction of Silver Nitrate with Peptidoglycan-Associated lipoprotein (Pal)

Abstract

Silver nitrate is an inorganic compound with chemical formula AgNO3. Silver or silver ions have long been used in many areas due to their strong antimicrobial activity against pathogenic microbes such as bacteria, yeast, fungi and algae. The protein Pal (peptidoglycan-associated lipoprotein) is anchored in the outer membrane (OM) of Gram-negative bacteria and interacts with Tol proteins. We used Molegro virtual docker (MVD). The results obtained from docking showed us that the best pose which is derived from MolDock score for Chitinase was -23.4702 with reranking score equal to -33.6883. Bioinformatic studies show that silver nitrate has interaction with protein Pal.