Comparison of single photon emission computed tomography-computed tomography, computed tomography and magnetic resonance imaging of medication-related osteonecrosis of jaw by new calculated parameters.

IF 2.7 3区物理与天体物理 Q2 PHYSICS, APPLIED

Journal of Applied Physics Pub Date : 2024-06-01 Epub Date: 2022-10-26 DOI:10.23736/S1824-4785.22.03483-5

Yoshiyuki Minami, Ichiro Ogura

{"title":"Comparison of single photon emission computed tomography-computed tomography, computed tomography and magnetic resonance imaging of medication-related osteonecrosis of jaw by new calculated parameters.","authors":"Yoshiyuki Minami, Ichiro Ogura","doi":"10.23736/S1824-4785.22.03483-5","DOIUrl":null,"url":null,"abstract":"Background: This study aimed to investigate parameters for medication-related osteonecrosis of jaw (MRONJ) patients using the bone SPECT/CT, especially bone mineral-based parameters.Methods: Sixty-three patients with MRONJ (43 osteoporosis and 20 bone metastasises) underwent CT, MRI and SPECT/CT. A commercially available software automatically detected lesion area and calculated the quantitative SPECT/CT parameters as bone mineral-based standardized uptake value (SUV).Results: Regarding stage of MRONJ patients, bone mineral based maximum SUV of stage 3 was significantly higher than stage 1, 2 (P=0.018). Regarding duration of medication therapy, bone mineral based maximum SUV 1 year or more was significantly higher than less than 1 year (P=0.019). Regarding present of periosteal bone proliferation on CT, bone mineral based maximum SUV was significantly higher than those of absent (P=0.029). Regarding spread of soft tissue inflammation on MRI, bone mineral based maximum SUV of 2 or more was significantly higher than those of less than 2 spaces (P=0.025). Regarding blood pool phase imaging with SPECT, bone mineral based maximum SUV of intense uptake was significantly higher than those of decrease uptake (P=0.002).Conclusions: SPECT/CT bone mineral-based parameters indicated significant difference in staging, dosing period, periosteal bone proliferation on CT, spread of soft tissue inflammation on MRI, and blood phase imaging with SPECT. Bone SPECT/CT bone mineral-based parameters are helpful for the assessment of MRONJ.","PeriodicalId":15088,"journal":{"name":"Journal of Applied Physics","volume":"72 1","pages":"126-132"},"PeriodicalIF":2.7000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Applied Physics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23736/S1824-4785.22.03483-5","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/10/26 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PHYSICS, APPLIED","Score":null,"Total":0}

引用次数: 0

Abstract

Background: This study aimed to investigate parameters for medication-related osteonecrosis of jaw (MRONJ) patients using the bone SPECT/CT, especially bone mineral-based parameters.

Methods: Sixty-three patients with MRONJ (43 osteoporosis and 20 bone metastasises) underwent CT, MRI and SPECT/CT. A commercially available software automatically detected lesion area and calculated the quantitative SPECT/CT parameters as bone mineral-based standardized uptake value (SUV).

Results: Regarding stage of MRONJ patients, bone mineral based maximum SUV of stage 3 was significantly higher than stage 1, 2 (P=0.018). Regarding duration of medication therapy, bone mineral based maximum SUV 1 year or more was significantly higher than less than 1 year (P=0.019). Regarding present of periosteal bone proliferation on CT, bone mineral based maximum SUV was significantly higher than those of absent (P=0.029). Regarding spread of soft tissue inflammation on MRI, bone mineral based maximum SUV of 2 or more was significantly higher than those of less than 2 spaces (P=0.025). Regarding blood pool phase imaging with SPECT, bone mineral based maximum SUV of intense uptake was significantly higher than those of decrease uptake (P=0.002).

Conclusions: SPECT/CT bone mineral-based parameters indicated significant difference in staging, dosing period, periosteal bone proliferation on CT, spread of soft tissue inflammation on MRI, and blood phase imaging with SPECT. Bone SPECT/CT bone mineral-based parameters are helpful for the assessment of MRONJ.

查看原文本刊更多论文

通过新计算参数比较颌骨骨坏死的单光子发射计算机断层扫描-计算机断层扫描、计算机断层扫描和磁共振成像。

背景：本研究旨在利用骨SPECT/CT检查药物相关性颌骨坏死（MRONJ）患者的参数，尤其是骨矿物质参数：本研究旨在通过骨SPECT/CT检查药物相关性颌骨坏死（MRONJ）患者的参数，尤其是基于骨矿物质的参数：63名MRONJ患者（43名骨质疏松症患者和20名骨转移患者）接受了CT、MRI和SPECT/CT检查。一个市售软件自动检测病灶面积，并以基于骨矿的标准化摄取值（SUV）计算 SPECT/CT 定量参数：结果：关于 MRONJ 患者的分期，3 期患者的骨矿物质最大 SUV 值明显高于 1、2 期患者（P = 0.018）。在药物治疗时间方面，1 年或以上的骨矿物质最大 SUV 值明显高于 1 年以下（P = 0.019）。关于 CT 显示的骨膜骨质增生，基于骨矿的最大 SUV 值明显高于未显示者（P = 0.029）。在核磁共振成像中，软组织炎症扩散时，骨矿物质最大 SUV 值为 2 或以上的患者明显高于不足 2 个空格的患者（P = 0.025）。在SPECT的血池相成像方面，基于骨矿物质的最大SUV摄取强烈的明显高于摄取减少的（P = 0.002）：结论：SPECT/CT骨矿物质参数在分期、用药时间、CT骨膜骨质增生、MRI软组织炎症扩散和SPECT血相成像方面均存在明显差异。基于骨SPECT/CT的骨矿物质参数有助于评估MRONJ。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Applied Physics 物理-物理：应用

CiteScore

5.40

自引率

9.40%

发文量

1534

审稿时长

2.3 months

期刊介绍： The Journal of Applied Physics (JAP) is an influential international journal publishing significant new experimental and theoretical results of applied physics research. Topics covered in JAP are diverse and reflect the most current applied physics research, including: Dielectrics, ferroelectrics, and multiferroics- Electrical discharges, plasmas, and plasma-surface interactions- Emerging, interdisciplinary, and other fields of applied physics- Magnetism, spintronics, and superconductivity- Organic-Inorganic systems, including organic electronics- Photonics, plasmonics, photovoltaics, lasers, optical materials, and phenomena- Physics of devices and sensors- Physics of materials, including electrical, thermal, mechanical and other properties- Physics of matter under extreme conditions- Physics of nanoscale and low-dimensional systems, including atomic and quantum phenomena- Physics of semiconductors- Soft matter, fluids, and biophysics- Thin films, interfaces, and surfaces