Scientific and Practical Innovations in Restoring Skin Barrier Properties in Children with Atopic Dermatitis

N. Murashkin, R. N. Nezhvedilova, D. V. Fedorov, R. Epishev, R. A. Ivanov, A. I. Materikin, L. A. Opryatin, A. A. Savelova, L. L. Rusakova
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Abstract

Atopic dermatitis (AD) is a multifactorial inflammatory skin disease. Its pathogenetic basis is epidermal barrier dysfunction, immune system dysregulation, as well as skin microbiome diversity decrease that occurs due to genetic predisposition. Considering these factors, the skin of patients with AD requires constant care and use of medications with active regenerative properties. The inclusion of anti-inflammatory components in the composition of modern emollients (zinc sulfate and sucralfate) is crucial for restoring the microbiome and immune mechanisms controlling the skin. This article presents data on pathogenetic applicability and clinical efficacy of emollients with anti-inflammatory compounds in patients with AD.
特应性皮炎患儿皮肤屏障特性恢复的科学与实践创新
特应性皮炎(AD)是一种多因素炎症性皮肤病。其发病基础是由于遗传易感性引起的表皮屏障功能障碍、免疫系统失调以及皮肤微生物群多样性减少。考虑到这些因素,阿尔茨海默病患者的皮肤需要持续的护理和使用具有活性再生特性的药物。在现代润肤剂(硫酸锌和硫硫钠)的成分中包含抗炎成分对于恢复微生物群和控制皮肤的免疫机制至关重要。本文介绍含抗炎成分的润肤剂对AD患者的发病适用性及临床疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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