Alcohol use disorder relapse factors: an exploratory investigation of craving, alcohol dependence severity, and meaning in life

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-03-26 DOI:10.1080/16066359.2022.2040488

W. Sliedrecht, H. Seesink, C. Vrijmoeth, Ranne de Waart, R. Wiers, B. Ostafin, H. Schaap-Jonker, H. Roozen, K. Witkiewitz, G. Dom

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引用次数: 5

Abstract

Abstract For decades predictors of alcohol use disorder (AUD) relapse have been studied, and around 40 different clinical and demographic relapse determinants have been identified. This paper aims to investigate the relationship of two of these AUD relapse factors, namely craving and meaning in life (MiL). We hypothesized that greater meaning in life would be associated with lower cravings and lower relapse rates. An AUD subsample of 81 patients within a clinical population that participated in ongoing exploratory research on religious/spiritual factors related to substance use disorders was followed up to 1 year. Craving (as measured with the Penn Alcohol Craving Scale) and meaning in life (as measured with the Meaning in Life Questionnaire- presence subscale) measures were assessed at baseline and relapse was assessed at 6- and 12-month follow up. Main effects and the interaction between craving and meaning in life in predicting alcohol relapse (with relapse defined as ‘any alcohol use’ and ≥ 3 consecutive days of drinking) were calculated/subject of analyses. We also investigated the relationship between relapse and alcohol dependence severity as measured with the Leeds Dependence Questionnaire. Baseline craving and dependence severity were related to relapse, but there were no associations between meaning in life and levels of craving or alcohol relapse. Our findings suggest a need for additional research on characterizing the Meaning in Life concept.

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酒精使用障碍复发因素:渴望、酒精依赖严重程度和生活意义的探索性调查

几十年来，人们一直在研究酒精使用障碍(AUD)复发的预测因素，并确定了大约40种不同的临床和人口学复发决定因素。本文旨在探讨其中两个AUD复发因素，即渴望和生活意义(MiL)之间的关系。我们假设，生活中更大的意义与更低的渴望和更低的复发率有关。在参与正在进行的与物质使用障碍相关的宗教/精神因素探索性研究的临床人群中，对81名患者进行AUD亚样本随访1年。在基线时评估渴望(用Penn酒精渴望量表测量)和生活意义(用生活意义问卷-存在子量表测量)，在6个月和12个月的随访中评估复发情况。计算了预测酒精复发(复发定义为“任何酒精使用”和连续饮酒≥3天)的主要效应和渴望与生活意义之间的相互作用。我们也用利兹依赖问卷调查了复发和酒精依赖严重程度之间的关系。基线渴望和依赖严重程度与复发有关，但生活意义与渴望程度或酒精复发之间没有关联。我们的研究结果表明，有必要对“生命意义”概念进行进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.