Genes and Family Environment Explain Correlations Between Blood Pressure and Body Mass Index

J. Cui, J. Hopper, S. Harrap
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引用次数: 102

Abstract

The correlations between systolic blood pressure (SBP) and diastolic blood pressure (DBP), and between SBP and body mass index (BMI), might result from genetic or environmental factors that determine variation in 2 or more phenotypes and are shared by family members. In 767 adult nuclear families (n=2912 individuals, including 66 pairs of monozygotic twins and 84 pairs of dizygotic twins), we used a multivariate normal model and the software FISHER to estimate genetic and environmental components of variation and covariation. Mean phenotypes were adjusted for age, gender, and generation, and for antihypertensive treatment. Genetic and shared family environmental factors accounted for 46% and 31% of total variance in SBP, respectively. Adjustment of SBP for DBP reduced considerably both the additive genetic (86.7 to 21.0) and shared environmental (59.7 to 21.0) components of variance. Smaller reductions in genetic (86.7 to 84.9) and shared environmental (59.7 to 51.1) components were observed after adjustment of SBP for BMI. For SBP and DBP, the correlation between the effects of genes was 1.00 and between shared environmental effects was 0.52. For SBP and BMI the correlations were 0.30 for genetic and 0.22 for shared environmental effects. Our findings suggest that the same genes and many of the same family environmental factors determine variation in both SBP and DBP. In contrast, SBP and BMI share genetic and family environmental determinants to a lesser degree. These observations are relevant to multifactorial cardiovascular risk reduction based on genetic and family environmental approaches.
基因和家庭环境解释血压和体重指数的相关性
收缩压(SBP)和舒张压(DBP)之间以及收缩压(SBP)和体重指数(BMI)之间的相关性可能是由遗传或环境因素决定的,这些因素决定了2种或更多表型的变异,并由家庭成员共享。在767个成人核心家庭(n=2912个人,包括66对同卵双胞胎和84对异卵双胞胎)中,我们使用多元正态模型和FISHER软件来估计变异和协变的遗传和环境因素。平均表型根据年龄、性别、世代和抗高血压治疗进行调整。遗传和共有的家庭环境因素分别占SBP总方差的46%和31%。舒张压对舒张压的调整大大降低了加性遗传(86.7 - 21.0)和共享环境(59.7 - 21.0)方差成分。根据BMI调整收缩压后,遗传因子(86.7 - 84.9)和共同环境因子(59.7 - 51.1)的降低幅度较小。对于收缩压和舒张压,基因效应之间的相关系数为1.00,共同环境效应之间的相关系数为0.52。SBP和BMI的遗传相关性为0.30,共同环境影响相关性为0.22。我们的研究结果表明,相同的基因和许多相同的家庭环境因素决定了收缩压和舒张压的变化。相比之下,收缩压和BMI在较小程度上具有遗传和家庭环境决定因素。这些观察结果与基于遗传和家庭环境方法的多因素心血管风险降低有关。
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