Kinetic Resolution of β- and γ-Hydroxy Sulfides by Fungal Lipase from Humicola lanuginosa

Abstract

Racemic g - and n -hydroxy sulfides were resolved by Humicola lanuginosa lipase catalyzed transesterification using vinyl acetate both as acyl donor and solvent. The effect of substituents and spacer length on rate of reaction and enantioselectivity is observed.