A facile synthesis of 4-naphthyl-3-cyano-2-(β-d-pyranosylthio) pyridines

Abstract

The treatment of piperidinium salt of 4-naphthyl-3-cyano-2-thiopyridines with an O -peracetyl-α-D-pyranosyl bromide in dry acetone provides a new and simple method for the synthesis of 2-(β-D-pyranosylthio) pyridines in high yields. The site of glycosylation on the pyridine ring was confirmed by 1 H and 13 C NMR spectral analysis.