scIAMC:Single-Cell Imputation via adaptive matrix completion

Abstract

Single-cell sequencing techniques are often impacted by technical noise, leading to the generation of very sparse expression matrices. This technical noise is referred to as dropouts and poses as a major challenge for downstream analysis. In this study, we introduce scIAMC (single-cell imputation via adaptive parameter matrix completion), which is based on matrix completion theory to recover missing values in expression matrices. To expedite the algorithm's running time and avoid any parameter tuning on data, we formulated an optimization problem. Our approach led to an enhanced cell population identification and minimal errors, while also restoring biological landscapes that were damaged by these dropouts.