Stainless steel and titanium alloys coated with sulfated chitosan to improve hemocompatibility properties.

IF 2.4
In vitro models Pub Date : 2023-06-14 eCollection Date: 2023-11-01 DOI:10.1007/s44164-023-00044-1
Sandy Danielle Lucindo Gomes, Maria Rosiene Antunes Arcanjo, Francisca Raysse Mesquita Silva, Luzia Kalyne Almeida Moreira Leal, Ana Paula Rosifini Alves Claro, Ketul Popat, Rodrigo Silveira Vieira
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Abstract

The main drawbacks of blood-contacting metallic devices are corrosion and thrombus formation on the surface, so polymeric coatings have been proposed to improve its hemocompatibility. Sulfated chitosan (SC) was obtained from natural chitosan (NC) reaction with chlorosulfonic acid to be used as a coating for metallic surfaces. The sulfated chitosan showed no platelet aggregation, an extended clotting time, and non-toxicity to rat fibroblast L929 cells. In this study, stainless steel (SS) and titanium alloys modified with TiO2 nanotube (NTT) growth received a NC and SC coating. The titanium surface coated with sulfated chitosan presented the lowest percentage of platelet coverage area. Sulfated chitosan proved to be a promising material for use as a coating for metallic surfaces applied for cardiovascular devices.

不锈钢和钛合金包覆硫酸壳聚糖,改善血液相容性。
接触血液的金属装置的主要缺点是腐蚀和表面形成血栓,因此提出了聚合物涂层来改善其血液相容性。以天然壳聚糖(NC)为原料,与氯磺酸反应制得硫酸化壳聚糖(SC),用于金属表面的涂层。磺化壳聚糖对大鼠成纤维细胞L929无血小板聚集、凝血时间延长、无毒性。在本研究中,采用TiO2纳米管(NTT)生长对不锈钢(SS)和钛合金进行了NC和SC涂层。硫酸壳聚糖包覆钛表面的血小板覆盖率最低。硫酸壳聚糖被证明是一种很有前途的用于心血管设备金属表面涂层的材料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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