Effects of 7-day supplementation with escalating doses of citrulline nitrate on resting and post-exercise blood pressure and safety biomarkers in healthy men: A randomized controlled trial

N. Todorovic, V. Štajer, L. Rátgéber, J. Betlehem, P. Acs, S. Ostojić
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Abstract

We investigated the effects of 7-day supplementation with three different dosages of citrulline nitrate (CN) on blood pressure at rest and after exercise, biochemical safety markers, and self-reported outcome measures of adverse events in healthy men. 12 apparently healthy young men (age 25.9 ± 4.0 years; weight 78.6 ± 10.0 kg, height 181.0 ± 7.0 cm) volunteered to participate in this double-blind, randomized, placebo-controlled cross-over trial. The dosages of CN were 1.5 g per day (low dose), 3.0 g per day (medium dose), and 6.0 g per day (high dose). No significant differences were found for systolic and diastolic blood pressure and heart rate at rest and after exercise between varying doses of CN and placebo (p > 0.05). In addition, hematological indices, biochemical variables, and clinical enzyme profiles were not affected by either intervention (p > 0.05), and the type and frequency of side effects were comparable to the placebo group. Citrulline nitrate was safe and well tolerated when administered for 7 days in dosages up to 6 g per day.
一项随机对照试验:在健康男性中,7天补充逐渐增加剂量的硝酸瓜氨酸对静息和运动后血压及安全生物标志物的影响
我们研究了在健康男性中,补充三种不同剂量的硝酸瓜氨酸(CN) 7天对休息和运动后血压、生化安全指标和不良事件自我报告结局测量的影响。健康青年男性12例(年龄25.9±4.0岁);体重78.6±10.0 kg,身高181.0±7.0 cm)自愿参加本双盲、随机、安慰剂对照交叉试验。CN的剂量为1.5 g / d(低剂量)、3.0 g / d(中剂量)和6.0 g / d(高剂量)。不同剂量的CN与安慰剂在静息和运动后的收缩压、舒张压和心率方面无显著差异(p > 0.05)。此外,两种干预均未影响血液学指标、生化指标和临床酶谱(p > 0.05),副作用的类型和频率与安慰剂组相当。以每天6克的剂量给药7天,硝酸瓜氨酸是安全且耐受性良好的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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